Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-089-2 | CAS number: 629-40-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
A Mouse Local Lymph Node Assay is available with a structural analogue of the test substance. The skin sensitising study was performed according to the OECD guideline 429 under GLP conditions with 1,4-Dicyanobutane, (CAS No.: 111-69-3; C6H8N2) that is supposed to have similar properties as the test substance (1,6-Dicyanohexane; C8H12N2). 5 female CBA/J mice per dose were treated with different concentrations (25%, 50% and 100% w/w) of the test substance (> 99% pure) in dimerthyl formamide.The mean disintegration per minute (DPM) was 314, 448, 610 and 443 for 25%, 50%, 100% and vehicle control group, respectively. The corresponding SI values were 0.7, 1.0, 1.4 and 1.0. One animal (100%) died and one moribund animal (50%) was killed during the study, but the deaths were not considered to be substance related, because no symptoms of toxicity were observed in the surviving animals. The study is considered reliable and suitable for assessment as it was performed according to guideline under GLP conditions. Based on the results of this study, the substance is not a skin sensitizer (Invista, 2009).
Migrated from Short description of key information:
Skin sensitisation (LLNA, GLP): not sensitising; Read across CAS No.: 111-69-3
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data available on respiratory sensitisation.
Justification for classification or non-classification
Dangerous substance Directive (67/548/EEC)
The available experimental test data are considered reliable and suitable for the purpose of classification. Based on the criteria for classification of skin sensitisation of Directive 67/548/EEC, as amended for the 28thtime in Directive 2001/59/EC, classification for skin sensitisation is not warranted.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification. Based on the criteria laid down in Regulation (EC) No. 1272/2008, as amended for the 2ndtime in Directive EC 286/2011, classification for skin sensitisation is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
