Registration Dossier
Registration Dossier
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EC number: 211-089-2 | CAS number: 629-40-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- Principles of method if other than guideline:
- 5-10 mice/sex/dose were administered intraperitoneally different doses of the test substance and were observed for 14 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Suberonitrile
- EC Number:
- 211-089-2
- EC Name:
- Suberonitrile
- Cas Number:
- 629-40-3
- Molecular formula:
- C8H12N2
- IUPAC Name:
- octanedinitrile
- Details on test material:
- - Name of test substance (as cited in study report): Korksaeuredinitril
- Analytical purity: no data
- Substance No.: XIII/213
- Sample No.: C 520/326
- Physical state: liquid
- Density: 0.942 g/mL
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other:
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details reported.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Traganth
- Doses:
- 1600, 200, 160 and 100 mL/kg bw (corresponding to approx. 1507, 188, 151 and 942 mg/kg bw; calculated assuming test substance density = 0.942 g/mL)
- No. of animals per sex per dose:
- 5 - 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 94 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated assuming test substance density = 0.942 g/mL
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 100 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
- Mortality:
- - 1600 mL/kg bw: 5/5 (within 1 hour)
- 200 mL/kg bw: 3/5 (within 1 day)
- 160 mL/kg bw: 9/10 (within 1 day)
- 100 mL/kg bw: 9/20 (4 within 1 hour, 5 within 1 day) - Clinical signs:
- intermittent respiration, abdominal-lateral position, tremor, poor general condition
- Body weight:
- Mean weights at study initiation:
- Males: 27.8 g
- Females: 25.2 g - Gross pathology:
- - Died animals: pale liver and kidney
- Sacrificed animals: no abnormalities
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
