Registration Dossier
Registration Dossier
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EC number: 211-089-2 | CAS number: 629-40-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- Principles of method if other than guideline:
- 5-10 mice/sex/dose were administered intraperitoneally different doses of the test substance and were observed for 14 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Suberonitrile
- EC Number:
- 211-089-2
- EC Name:
- Suberonitrile
- Cas Number:
- 629-40-3
- Molecular formula:
- C8H12N2
- IUPAC Name:
- octanedinitrile
- Details on test material:
- - Name of test substance (as cited in study report): Korksaeuredinitril
- Analytical purity: no data
- Substance No.: XIII/213
- Sample No.: C 520/326
- Physical state: liquid
- Density: 0.942 g/mL
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other:
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details reported.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Traganth
- Doses:
- 1600, 200, 160 and 100 mL/kg bw (corresponding to approx. 1507, 188, 151 and 942 mg/kg bw; calculated assuming test substance density = 0.942 g/mL)
- No. of animals per sex per dose:
- 5 - 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 94 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated assuming test substance density = 0.942 g/mL
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 100 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
- Mortality:
- - 1600 mL/kg bw: 5/5 (within 1 hour)
- 200 mL/kg bw: 3/5 (within 1 day)
- 160 mL/kg bw: 9/10 (within 1 day)
- 100 mL/kg bw: 9/20 (4 within 1 hour, 5 within 1 day) - Clinical signs:
- intermittent respiration, abdominal-lateral position, tremor, poor general condition
- Body weight:
- Mean weights at study initiation:
- Males: 27.8 g
- Females: 25.2 g - Gross pathology:
- - Died animals: pale liver and kidney
- Sacrificed animals: no abnormalities
Applicant's summary and conclusion
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