Registration Dossier
Registration Dossier
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EC number: 225-756-0 | CAS number: 5056-17-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (E,E,E)-2,7-dimethylocta-2,4,6-trienedial
- EC Number:
- 225-756-0
- EC Name:
- (E,E,E)-2,7-dimethylocta-2,4,6-trienedial
- Cas Number:
- 5056-17-7
- Molecular formula:
- C10H12O2
- IUPAC Name:
- (E,E,E)-2,7-dimethylocta-2,4,6-trienedial
- Test material form:
- liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
Results and discussion
Test results
- Species / strain:
- other: TA98, TA100, TA1535, TA1537 and TA102
- Remarks:
- all negative
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- In conclusion, it can be stated that during the described mutagenicity test and under the experimental conditions reported, C10-Dial did not cause gene mutations by base pair changes or frameshifts in the genome of the tester strains used.
Therefore, C10-Dial is considered to be non-mutagenic in this bacterial reverse mutation assay. - Executive summary:
In conclusion, it can be stated that during the described mutagenicity test and under the experimental conditions reported, C10-Dial did not cause gene mutations by base pair changes or frameshifts in the genome of the tester strains used.
Therefore, C10-Dial is considered to be non-mutagenic in this bacterial reverse mutation assay.
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