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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
publication
Title:
Preliminary toxicological studies on nitrogen trifluoride
Author:
Torkelson, T. R., Oyen, F., Sadek, S. E. & Rowe, V. K.
Year:
1962
Bibliographic source:
Toxicological and applied pharmacology, 4, pp 770-781.

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrogen trifluoride
EC Number:
232-007-1
EC Name:
Nitrogen trifluoride
Cas Number:
7783-54-2
Molecular formula:
F3N
IUPAC Name:
trifluoroamine
Test material form:
gas

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
7 injections, 2-6 d apart over a 23-d period
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
10 mL of undiluted NF3
No. of animals per sex per dose:
4/gp
Control animals:
yes

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Description (incidence and severity):
Rabbits gained weight and were normal in appearance during the entire experiment.
Body weight and weight changes:
no effects observed
Description (incidence and severity):
Rabbits gained weight and were normal in appearance during the entire experiment.
Immunological findings:
no effects observed
Description (incidence and severity):
Stained smears or peripheral blood and bone marrow did not reveal any abnormal changes.
Gross pathological findings:
effects observed, treatment-related
Description (incidence and severity):
At autopsy no evidence of local irritation was seen in the peritoneal cavity. The teeth were normal in appearance.
Enlargement of the spleen of the treated animals was the only abnormality seen during gross pathological examination.
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Description (incidence and severity):
Centriolobular vacuolisation of the cytoplasm were observed in the liver, with liver cells appearing larger than normal. Myocardial degeneration was seen in the hearts of the treated animals. The sinuses of the spleens were distended and RBC had infiltrated the pulp. There was also a moderate increase in the connective tissue of the spleen. Analysis of several wet tissues for total fluroride content indicated an increase in the fluoride content of the blood, bones and teeth and is evidenced that NF3 was in part metabolised.

Effect levels

Dose descriptor:
NOAEL
Basis for effect level:
other: increased wts of heart, liver, spleen with microscopic changes observed. Total fluoride content was increased in blood, bones and teeth
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The effects observed acutely were not observed following repeated exposure, this may be due to the fact that MetHb is more difficult to produce in the rabbit than the rat (at least this is true for acetanilide and acetophenetidine).

Applicant's summary and conclusion