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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not comply with current guidelines for acute inhalation testing.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
To investigate the effects of inhaling a substantially saturated vapour of test substance.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 6 h
Concentrations:
"Substantially saturated vapour"
No. of animals per sex per dose:
Five
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Remarks on result:
other: Not determined as only two of 10 animals died at the single concentration tested.

Any other information on results incl. tables

Two male (no female) rats died following a single 6-hour inhalation exposure to substantially saturated vapour of Y-9445. Both had dark red lungs at necropsy. Signs of toxicity for males and females included hypoactivity, salivation, lacrimation, dermal irritation (erythema), coordination loss and prostration.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In a non-guideline acute inhalation study, not conducted to GLP, the LC50 for 3-(trimethoxysilyl)propiononitrile was greater than the "substantially saturated vapour".