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Diss Factsheets
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EC number: 214-447-6 | CAS number: 1129-42-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Data on the toxicity of 6-methyl-2-oxoperhydropyrimidin-4-yl urea
to terrestrial organisms are not available.
In accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. the
assessment of the toxicity of the substance to soil macroorganisms is
based on information on the structurally related substance
N,N''-(isobutylidene)diurea (CAS No 6104-30-9).
6-methyl-2-oxoperhydropyrimidin-4-yl urea (CAS No 1129-42-6) and
N,N''-(isobutylidene)diurea (CAS No 6104-30-9) show extensive structural
similarities. These similarities comprise the molecular structure of
both substances as well as their molecular masses
(N,N''-(isobutylidene)diurea: 174 g/mol,
6-methyl-2-oxoperhydropyrimidin-4-yl urea: 172 g/mol). The potential of
both analogue substances to bioaccumulate is low according to their log
Kow values (N,N''-(isobutylidene)diurea: -0.9;
6-methyl-2-oxoperhydropyrimidin-4-yl urea: -1.34). Both substances are
slightly soluble with a water solubility of 0.3 up to 3 g/L for
N,N''-(isobutylidene)diurea and 5.1 g/L for
6-methyl-2-oxoperhydropyrimidin-4-yl urea respectively. Both substances
are characterized by a low adsorption potential (log Koc
N,N''-(isobutylidene)diurea: 1.4, log Koc
6-methyl-2-oxoperhydropyrimidin-4-yl urea: 0.098) and by a low vapour
pressure (VP N,N''-(isobutylidene)diurea: 4.7 E-12 Pa, VP
6-methyl-2-oxoperhydropyrimidin-4-yl urea: < 0.35 Pa). Thus a similar
toxicity of the analogue substances can be expected.
For the structural analogue N,N''-(isobutylidene)diurea (CAS No 6104-30-9) on study investigating the toxicity of the substance to earthworms is available. The test was conducted according to guideline 207. Earthworms of the species Eisenia fetida were exposed to the substance for 14 days. At test termination a LC50 of 648 mg/kg soil was determined (NOEC: 250 mg/kg).
Based on the chemical safety assessment and in accordance with Regulation (EC) No. 1907/2006, Annex IX, column 2, 9.4 further studies on the effect of 6-methyl-2-oxoperhydropyrimidin-4-yl urea on terrestrial organisms were not conducted. The substance is not expected to induce acute or chronic effects in terrestrial organisms due to the physic-chemical properties and expected environmental fate. The bioavailability the substance for soil organisms is expected to be very low. The substance is readily biodegradable thus transfer of the substance to soil or persistence in soil is not likely. The substance is furthermore characterised by a low log Koc indicating a low potential to adsorb to soil particles and suspended matter and to accumulate in soils. Accumulation of the substance in organisms is also unlikely as indicated by the low log Kow. Thus based on data for soil macroorganisms obtained by read-across and on the expected environmental fate of the substance acute and chronic effects to soil organisms are not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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