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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The SI values calculated for the substance concentrations 25, 50 and 100% were 1.2, 1.5 and 1.1 respectively. Since there was no indication that the test substance elicit an SI = 3 when tested up to 100%, Biomass residue (liquid) obtained after B2 production was considered to be a non skin sensitizer. The six-monthly reliability check with Hexylcinnamaldehyde, indicates that the Local Lymph Node Assay as performed at NOTOX is an appropriate model for testing for contact hypersensitivity.


Migrated from Short description of key information:
A reliable LLNA test performed according to OECD and EU guidelines as well as GLP principles is available.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification

Based on these results Biomass residue (liquid) obtained after B2 production would not be regarded as skin sensitizer according to the recommendations made in the test guidelines and does not have to be classified and has no obligatory labeling requirement for sensitization by skin contact according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations (2007) and the Regulation (EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures.

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