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EC number: 209-047-3 | CAS number: 553-72-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Zinc oxide
- EC Number:
- 215-222-5
- EC Name:
- Zinc oxide
- Cas Number:
- 1314-13-2
- Molecular formula:
- ZnO
- IUPAC Name:
- oxozinc
- Reference substance name:
- Z-Cote HP1
- IUPAC Name:
- Z-Cote HP1
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Charles River, Sulzefeld, Germany- Age at study initiation: 10 - 11 weeks- Weight at study initiation: males (mean): 308.92 g, females (mean): 193.28 g- Housing: 2 rats of same sex per cage, wooden absorbing bedding- Diet (e.g. ad libitum): ad libitum- Water (e.g. ad libitum): ad libitum- Acclimation period: 4 weeksENVIRONMENTAL CONDITIONS- Temperature (°C): 22 +/- 2°C- Humidity (%): 55 +/- 15%- Air changes (per hr): fully airconditioning- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE- Area of exposure: backREMOVAL OF TEST SUBSTANCE- Washing (if done): water- Time after start of exposure: 24 hTEST MATERIAL- Amount(s) applied (volume or weight with unit): 2000mg/kg bw- Concentration (if solution): 0.5mg test item in 400µl corn oil- Constant volume or concentration used: no- For solids, paste formed: yes
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- other: untreated skin of same animal
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: twice a day, once on weekends- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, gross pathology
- Statistics:
- Means and standard deviation were calculated using standard statistical tests.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality occurred
- Mortality:
- not observed
- Clinical signs:
- other: slight signs of general discomfort as often seen in dermal toxicity studies, the general health status was good throughout the study
- Gross pathology:
- no abnormalties detected
Any other information on results incl. tables
During the present study no mortality occured and there were no indications of systemical toxicity, no effects regarding the body weight and neither clinical signs nor pathological findings observed. The LD50 is therefore estimated to be > 2000mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Executive summary:
2000 mg/kg bw of the test item were semiocclusively administered for 24 hours as pasty formulation in corn oil to the shaved and defaffed back of
5 female and 5 male rats. After the end of the 24 -hour exposure period the test item paste was recovered as effectively as possible using water and the animals were observed for 14 days.During the present study no mortality occured and there were no indications of systemical toxicity, no effects regarding the body weight and neither clinical signs nor pathological findings observed. The LD50 is therefore estimated to be > 2000mg/kg bw.
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