Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 260-252-4 | CAS number: 56539-66-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- According to REACH Annex VIII column 2, bioaccumulation testing can be waived for substances with a low potential for bioaccumulation (log Kow < 3). MMB has a log Kow < 1. Hence, bioaccumulation testing can be waived for this substance.
A QSAR calculation was done for the bioconcentration factor of MMB using BCFBAF v3.01 (as available in US EPA EPISUITE). It resulted in an estimated log BCF of 0.5 (BCF = 3.16 L/kg ww). The BCF for MMB is < 2000 L/Kg ww and therefore bioaccumulation of this substance is not expected - Principles of method if other than guideline:
- QSAR calculation using EPISUITE BCFBAF v3.01 (2012)
- Key result
- Type:
- BCF
- Value:
- 3.16 L/kg
- Basis:
- whole body w.w.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The predicted log BCF = 0.5 (3.16 L/kg) based on measured log Pow = 0.18.
Referenceopen allclose all
Description of key information
Estimated log BCF = 0.500 (BCF = 3.16 L/kg ww)
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.16 L/kg ww
Additional information
According to REACH Annex VIII column 2, bioaccumulation testing can be waived for substances with a low potential for bioaccumulation (log Kow < 3). MMB has a log Kow < 1. Hence, bioaccumulation testing can be waived for this substance.
A QSAR calculation was done for the bioconcentration factor of MMB using BCFBAF v3.01 (as available in US EPA EPISUITE). It resulted in an estimated log BCF of 0.5 (BCF = 3.16 L/kg ww). The BCF for MMB is < 2000 L/Kg ww and therefore bioaccumulation of this substance is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
