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Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The main study was not conducted as preliminary tests indicated that the substance was stable under the given conditions.
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes
Transformation products:
no
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
pH:
9
Temp.:
25 °C
DT50:
> 1 yr

Test results:

 Test solution     Initial concentration (mg/L) Measured value       Concentration after 5 days (mg/L)        Residual rate (%)  
 Measured value  Mean
    pH 4     202  202  100     99.0  
 198  97.9  
    pH 7     204  194  95.0     96.7  
 201  98.4  
    pH 9     188  195  104     105
 199  106

The substance was stable in water and its half-life at 25°C was greater than 1 year at pH 4, 7 and 9.

Validity criteria fulfilled:
not applicable
Conclusions:
In conclusion, preliminary tests indicate that the substance is stable in water having a half-life of more than a year at pH 4, 7 and 9 and 25°C.

Description of key information

Hydrolysis half-life: stable in water (t 1/2 > 1 yr at 25°C)

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

Hydrolysis half-lives were determined at pH 4, 7 and 9 at 50°C in a reliable preliminary study conducted according to an appropriate test protocol and in compliance with GLP. Hydrolysis half-lives were found to be greater than one year at 25°C and pH 4, 7 and 9. The result is considered to be reliable.