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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Type:
log Pow
Partition coefficient:
0.18
Temp.:
24.8 °C
pH:
6.4

Results of the measurement of partition coefficient

               POW=CO/CW        log POW
 Measured value  Mean value  Total mean value
          Measured condition 1  a  1.50  0.18     0.17       0.18 Standard deviation = 0.016Maximum difference = 0.03          
 b  1.48  0.17
          Measured condition 2  a  1.57  0.20 0.19    
 b  1.50  0.17
          Measured condition 3  a  1.60  0.20     0.19
 b  1.47  0.17

Results of pH measurement of water phase

         Measurement value
 Sample a  Sample b
 Measured condition 1  6.6  6.3
 Measured condition 2  6.5  6.3
 Measured condition 3  6.4  6.3
Conclusions:
In conclusion, the log octanol/water partition coefficient value of 0.18 at 24.8°C and pH 6.3 was obtained for 3-methoxy-3-methylbutan-1-ol using the shake-flask method.

Description of key information

Log Kow: 0.18 at 25°C

Key value for chemical safety assessment

Log Kow (Log Pow):
0.18
at the temperature of:
25 °C

Additional information

A partition coefficient Octanol/Water Log Kow = 0.18 at 24.8°C was reported in a reliable study, conducted according to an appropriate test protocol.