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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: isothermal thermogravimetry
Temp.:
20 °C
Vapour pressure:
47 Pa
Temp.:
25 °C
Vapour pressure:
80 Pa

Preliminary test

At 96°C the sample weight had decreased by 25%. After the experiment it was observed that the test substance was evaporated from the sample container.

Main study

The results of the isothermal TGA analysis for the test substance and the vapour pressure at 20°C and 25°C are given in table 1 and 2. The plot of the log PT of the test substance as function of the reciprocal temperatures can be described by the following equation: logPT,20 = -4024 * 1/T + 15.40 (r = 0.9998, n = 6)

Table 1 Results of the isothermal TGA analysis

 Temperature [°C]  Weight loss [µg/min]  vT [g/cm2/h]  log vT  log PT  PT [Pa]
 20  40.95  4.89*10 -3  -2.31  1.67  4.7*10 1
   41.48  4.95*10 -3  -2.31  1.68  4.7*101
25   65.32  7.80*10 -3  -2.11  1.90  8.0*10 1
   64.89  7.75*10 -3  -2.11  1.90  7.9*101
 30  102.2  1.22*10 -2  -1.91  2.13  1.3*102
   100.9  1.20*10 -2  -1.92  2.12  1.3*102

Table 2 Vapour pressure of the test substance

 Temperature [°C]  log PT  PT [Pa]  PT [mmHg]
 20  1.67  47  0.35
25   1.90  80  0.60

Conclusions:
A vapour pressure value of 47 Pa at 20°C was determined in a reliable study.

Description of key information

Vapour pressure: 47 Pa at 20°C; 80 Pa at 25°C

Key value for chemical safety assessment

Vapour pressure:
47 Pa
at the temperature of:
20 °C

Additional information

A vapour pressure value of 47 Pa at 20°C was determined in a reliable study conducted according to appropriate test protocol; this is the most reliable result and assigned as key study. A vapour pressure value of 125 Pa at 25°C was measured using the Siwoloff method. A vapour pressure of 67 Pa is reported in secondary literature (MSDS), of which the reliability is not assignable.