Registration Dossier

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study, validity criteria fulfilled

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Ephedrine hydrochloride
EC Number:
200-074-6
EC Name:
Ephedrine hydrochloride
Cas Number:
50-98-6
IUPAC Name:
2-(methylamino)-1-phenylpropan-1-ol hydrochloride
Details on test material:
- Name of test material (as cited in study report): (-)-Ephedrin-Hydrochlorid
- Lot/batch No.: 010722AX10
- Analytical purity: 99.5 %

Study design

Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge, domestic, non-adapted
Details on inoculum:
- Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge from laboratory wastewater plants treating municipal sewage.
- Concentration of sludge: 30 mg/l
Duration of test (contact time):
28 d
Initial test substance concentrationopen allclose all
Initial conc.:
20 mg/L
Based on:
DOC
Initial conc.:
34 mg/L
Based on:
test mat.
Parameter followed for biodegradation estimation
Parameter followed for biodegradation estimation:
DOC removal
Reference substance
Reference substance:
aniline

Results and discussion

% Degradation
Parameter:
% degradation (DOC removal)
Value:
ca. 90 - ca. 100
Sampling time:
18 d
Details on results:
Kinetic of test substance (in %):
< 0 after 5 day(s)
ca. 49 after 7 day(s)
ca. 94 after 10 day(s)
ca. 96 after 14 day(s)
ca. 98 after 18 day(s)
Kinetic of control substance (in %):
ca. 90 ... 100 after 14 day(s)

Any other information on results incl. tables

TOC=606 mg/g, DOC=611 mg/g; 10-day window met, adaptation phase: 6 days, degradation phase: 11 days;

Applicant's summary and conclusion

Interpretation of results:
readily biodegradable