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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined. No doses defined.

Data source

Reference
Reference Type:
publication
Title:
Evaluation of the toxicity of polyvinylacetate phthalate in experimental animals
Author:
Schoneker D.R. et al.
Year:
2002
Bibliographic source:
Food and Chemical Toxicology 41 (2003) 405-413

Materials and methods

Principles of method if other than guideline:
male and female albino mice weighing 18-20 g, were used. The animals were fasted for a period of 4-16 h prior to treatment. Range-finding tests of the acute toxicity were conducted initially. 5% gum acacia was used as the vehicle. All surviving animals were maintained for a subsequent 14-day period. The LD50 was calculated from the mortality data.
GLP compliance:
not specified
Test type:
other: acute oral toxicity in mice
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
mouse
Strain:
other: albino
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: 5% gum acacia
Doses:
no data
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

Any other information on results incl. tables

Phthalic acid, Mouse,LD50= >5000 mg/kg bw

Applicant's summary and conclusion

Executive summary:

In an acute oral toxicity study in male and female albino mice the LD50 was >5000 mg/kg bw.