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Long-term toxicity to aquatic invertebrates

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Description of key information

The long-term toxicity of phthalic anhydride to aquatic invertebrates was determined in a test conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test). A 21d-NOEC of 16 mg/L was obtained. The result is regarded with caution, since it cannot be excluded that the toxicity observed was due to pH effects based on the formation of phthalic acid during the experiment causing a pH shift. (MITI, 2003).

Key value for chemical safety assessment

Additional information

Due to fast hydrolysis the LC50-value obtained for phthalic anhydride was considered here to assess the environmental hazard of phthalic acid.

There is only one long-term toxicity test for phthalic anhydride towards aquatic invertebrates available. As no information is given on pH, it cannot be excluded that the toxicity observed was due to pH effects. A weight of evidence approach is applied, as the study is stated to be reliable, but should only be taken into account applying an appropriate assessment factor for PNEC derivation.