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Long-term toxicity to fish

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Concerning long-term toxicity of phthalic acid to fish, an early life stage toxicity test using phthalic anhydride as test substance was taken into account. The test was performed according to the Draft Guideline OECD 210, and was carried out in buffered medium using Salmo gairdneri (new name: Oncorhynchus mykiss) as test species. A NOEC of 10 mg/l was derived from the test results (Van Leeuwen, 1990).

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Due to fast hydrolysis the value of phthalic anhydride was considered here to
assess long-term toxicity to fish of phthalic acid. A chronic toxicity test
of phtalic anhydride to fish was performed with
Oncorhynchus mykiss (Salmo gairdneri) according to the
OECD Guideline Draft "Early Life Stage" 210 in buffered medium under semi static
conditions. Fertilised eggs and the following early-life stages of fish were
exposed to geometric series of 7 test concentrations for 60 days.
An effective LOEC of 32mg/l was determined. With a factor of 3.2 the next lowest
concentration is 10 mg/l which corresponds to the no effect concentration (NOEC.
Due to fast hydrolysis the value of phthalic anhydride was considered here to
assess long-term toxicity to fish of phthalic acid. A chronic toxicity test of
phtalic anhydride to fish was performed with Oncorhynchus mykiss (Salmo gairdneri)
according to the OECD Guideline Draft "Early Life Stage" 210 in buffered medium
under semi static conditions. Fertilised eggs and the following early-life stages
of fish were exposed to geometric series of 7 test concentrations for 60 days.
An effective LOEC of 32mg/l was determined. With a factor of 3.2 the next lowest
concentration is 10 mg/l which corresponds to the no effect concentration (NOEC).
Not only mortality but also other endpoints like total embryotoxicity were tested.