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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Principles of method if other than guideline:
In consideration of the relevance of granulometry study on toxicological assessment, only the size distributions of the sieved fraction < 100 µm were studied in detail.
GLP compliance:
not specified
Type of method:
sieving
Remarks:
followed by scanning electron microscopy.
Type of distribution:
counted distribution
Percentile:
D50
Mean:
>= 72 - <= 74 µm
Remarks on result:
other: calculated for the cubical volume(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)

The sample was first sieved by a 100µm sieve.

weighted sample:              0.5852 g

weight fraction < 100µm:   0.4988 g

mass fraction < 100µm:       85.2 %

The mass fraction < 100µm was 85.2 %, and was investigated by scanning electron microscopy. The median aspect ratio was 1.87.

The median diameter of the particle size is given for the fraction < 100µm. The value 72 µm was calculated for cubical, and the value 74 µm for spherical paritcles.

   spherical volume  cubical volume
 particle size  mass fraction  mass fraction
 < 4µm  0.004 %  0.005 %
 4 - 10 µm  0.08 %  0.08 %
 10 - 100 µm  72.44 %  78.19 %
> 100* 27.48 % 21.73 %
   median diameter  74 µm  72 µm

*Particles with diameter greater than 100 µm are due to their aspect ratios up to 4.1.

The particles whose aspect ratios were bigger than 1.75, passed the 100 µm sieve but were cosidered as particles with mean diameter higher than 100 µm.

Executive summary:

According to OECD guideline 110, the particle size distribution of phthalic acid was determined by scanning electron microscopy method for the sieved fraction (< 100 µm, 85.2 % of total sample) and presented on the basis of calculated mass fractions. The median diameter was 72 - 74 µm with the main fraction of 72 -78 % distributing in the range of 10 to 100 µm (Currenta, 2010); and hence the tested phthalic acid particles with sieved size smaller than 100 µm are mainly dominated by inhalable fraction as defined in EN 481.

Description of key information

According to OECD guideline 110, the particle size distribution of phthalic acid was determined by scanning electron microscopy method for the sieved fraction (< 100 µm, 85.2 % of total sample) and presented on the basis of calculated mass fractions. The median diameter was 72 - 74 µm with the main fraction of 72 -78 % distributing in the range of 10 to 100 µm (Currenta, 2010); and hence the tested phthalic acid particles with sieved size smaller than 100 µm are mainly dominated by inhalable fraction as defined in EN 481.

Additional information