Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
Further instructions
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
There are currently no ongoing consultations.
| Dialkyl-methyl-dihydro-heteropolycyle | 815-131-6 | 913171-06-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/03/2020 | 07/05/2020 | Details | |
| Dimethyl (p-methoxybenzylidene)malonate | 231-185-8 | 7443-25-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
| Dioctyltin dilaurate | 222-883-3 | 3648-18-8 | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
| Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide | 810-703-1 | 1187441-10-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
| tert-butyl perbenzoate | 210-382-2 | 614-45-9 | Long-term toxicity to fish | 23/03/2020 | 07/05/2020 | Details | |
| (1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol | 695-878-0 | 1283129-18-9 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| 2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide | 686-241-8 | 81058-27-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Dibutyl itaconate | 218-451-9 | 2155-60-4 |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Etocrilene | 226-029-0 | 5232-99-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Fluorobenzene | 207-321-7 | 462-06-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine | 695-748-3 | 65286-55-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide | 806-543-7 | 215917-77-4 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated | 846-447-2 | 1219458-07-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| 1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] | 284-366-9 | 84852-53-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/02/2020 | 09/04/2020 | Details | |
| 1,4-phenylenebis[(4-phenoxyphenyl)methanone] | 620-097-9 | 54299-17-1 | Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) | 24/02/2020 | 09/04/2020 | Details | |
| 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate | 261-665-2 | 59219-71-5 | Sub-chronic toxicity (90-day): oral | 24/02/2020 | 09/04/2020 | Details | |
| 4-tert-butylcyclohexyl acetate | 250-954-9 | 32210-23-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with cis-4-tert-butylcyclohexyl acetate |
24/02/2020 | 09/04/2020 | Details | |
| Camphene | 201-234-8 | 79-92-5 | Sub-chronic toxicity (90-day): oral | 24/02/2020 | 09/04/2020 | Details | |
| 2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 260-829-0 | 57583-35-4 |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- | 500-012-0 | 9004-77-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1). Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Reaction products of monoethanolamine and boric acid (1:1) | 701-025-6 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Reaction products of monoethanolamine and boric acid (1:3) | 701-024-0 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| 1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol | 264-261-4 | 63469-23-8 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| 2,2'-isopropylidenebis(p-phenyleneoxy)diethanol | 212-985-6 | 901-44-0 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| 3-[[3-[[(2-cyanoethyl)amino]methyl]-3,5,5-trimethylcyclohexyl]amino]propiononitrile | 300-496-1 | 93940-97-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Diethyl ethylphosphonate | 201-111-9 | 78-38-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| N,N'-diphenyl-p-phenylenediamine | 200-806-4 | 74-31-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Reaction products of orthoboric acid with 2,2'-iminodiethanol (1:1) | 701-083-2 | - |
Sub-chronic toxicity (90-day): oral “||Note: testing proposed with MEA Polyborate (EC 701-025-6)” "Reproductive toxicity (pre-natal developmental toxicity)
“||Note: testing proposed with MEA Polyborate (EC 701-025-6)” |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1) | 947-369-2 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| tetrahydro-2-methylfuran | 202-507-4 | 96-47-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| 1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
| 2-(2-(2-butoxyethoxy)ethoxy)ethanol | 205-592-6 | 143-22-6 | Reproductive toxicity (pre-natal developmental toxicity): 1st PNDT on the registered substance 2nd PNDT with the registered substance // Note: Testing proposal for an EOGRTS proposed to be conducted with the analogue substance 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1, CAS 112-35-6) | 27/01/2020 | 12/03/2020 | Details | |
| 4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride | 253-781-7 | 38103-06-9 | Sub-chronic toxicity (90-day): oral | 27/01/2020 | 12/03/2020 | Details | |
| 4,4'-methylenebis[N-sec-butylaniline] | 226-122-6 | 5285-60-9 | Bioaccumulation aquatic / sediment | 27/01/2020 | 12/03/2020 | Details | |
| 4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| Diethyl bis(2-hydroxyethyl)aminomethylphosphonate | 220-482-8 | 2781-11-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| Ethylenediamine, salt with phosphoric acid | 238-914-9 | 14852-17-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/01/2020 | 12/03/2020 | Details | |
| m-phenylene di(acetate) | 203-596-2 | 108-58-7 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
| N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine | 264-438-6 | 63738-22-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol | 907-996-4 | - | Reproductive toxicity (pre-natal developmental toxicity) 1st and 2nd PNDTs: || Note: testing proposed with 2-92-92-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) | 27/01/2020 | 12/03/2020 | Details | |
| Tetramethylammonium hydroxide | 200-882-9 | 75-59-2 | Sub-chronic toxicity (90-day): oral // Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8) || Note: Link to justification in the registration dossier not given as the information is confidential | 27/01/2020 | 12/03/2020 | Details | |
| Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate | 950-225-1 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8) |
17/12/2019 17/12/2019 |
31/01/2020 31/01/2020 |
Details | |
| 3-[(3-{[(3-acetoxy-2,2-dimethylpropylidene)amino]methyl}-3,5,5-trimethylcyclohexyl)imino]-2,2-dimethylpropyl acetate | 805-722-7 | 1064082-81-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
| isliFe | - | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
| Sodium hydrogen N-(1-oxotetradecyl)-L-glutamate | 253-981-4 | 38517-37-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with L-Glutamic acid, N-coco acyl derivs., disodium salts (CAS number: 68187-30-4; EC number: 269-085-1) || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
| 2,2'-(octylimino)bisethanol | 239-555-0 | 15520-05-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/11/2019 25/11/2019 |
09/01/2020 09/01/2020 |
Details | |
| 2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated | 500-022-5 | 9014-85-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 2,4,7,9-Tetramethyl-5-decyne-4,7-diol (CAS number 126-86-3) || |
25/11/2019 | 09/01/2020 | Details | |
| 2-hydroxy-3-propyl-2H-furan-5-one | 821-451-7 | 78920-10-2 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. || |
25/11/2019 | 09/01/2020 | Details | |
| Heptanal | 203-898-4 | 111-71-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Heptanoic acid (CAS No. 111-14-8) |
25/11/2019 | 09/01/2020 | Details | |
| Hexaboron dizinc undecaoxide | 235-804-2 | 12767-90-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. |
25/11/2019 | 09/01/2020 | Details | |