Registered substances
Registered substances
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
Please note:
- The REACH Registered substance portal was updated on 9th November 2020; the REACH registered factsheets were further updated on 21st December 2020. Details of the improvements can be found at Dissemination Platform Updates. Reprocessing the entire dataset is ongoing since 21 December 2020. ECHA is making all possible efforts to make the improvements and additional data visible with the shortest delay.
- The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
Further information
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Last updated 31 March 2021. Database contains 25847 unique substances and contains information from 99441 dossiers.
| Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
|---|---|---|---|---|---|---|---|---|
| Nalco Limited | P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| RSI ChemRep Europe Ltd (N001) | 27-30 Merchants Quay Merchants House 8 Dublin Ireland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| NAM & NAM Europe GmbH | Emil-Figge-Str. 80 44227 Dortmund(1007) Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| C.S.B. GmbH | Düsseldorfer Str. 113 47809 Krefeld Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| REACHLaw Ltd. | Vänrikinkuja 3 JK 21 02600 Espoo Finland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Huntsman Advanced Materials (Europe) BVBA | Everslaan 45 B-3078 Everberg Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Covestro Deutschland AG | Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| RHODIA OPERATIONS - 1 | 40 rue de la Haie Coq 93306 Aubervilliers France | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| PPG Europe B.V. - OR3 | Amsterdamseweg 14 1422 AD Uithoorn Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| CCD (Germany) GmbH | Graf-Adolf-Strasse 68 40210 Düsseldorf Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Kao Chemicals Europe, S.L. (10) | Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Henkel Global Supply Chain B.V. | Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Nalco Europe B.V. | Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Allnex Belgium NV/SA OR1 | Anderlechtstraat 33 1620 Drogenbos Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| LG Chem Europe GmbH | Lyoner str 15, Atricom C6, D-60528 Frankfurt am Main Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Covestro Deutschland AG OR CN_001554 | Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Huntsman Advanced Materials (Europe) BVBA OR-U | Everslaan 45 B-3078 Everberg Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Lubrizol Deutschland GmbH | Max-Planck-Strasse 6 27721 RITTERHUDE Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Caplinq Europe BV | De Trompet 1126 1967 DA Heemskerk - Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Cytec Engineered Materials GmbH in its legal capacity as OR of Cytec Industries Inc. | Industriestraße 3 76684 Östringen Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf) | Herzogstrasse 15 D-40217 Düsseldorf Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| TÜV SÜD Iberia S.A.U. (003) | Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Covestro NV | Haven 507 Scheldelaan 420 2040 Antwerpen Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Kao Chemicals Europe, S.L. (2) | Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Cytec Engineered Materials Ltd. | Abenbury Way Wrexham Industrial Estate LL13 9UZ Wrexham United Kingdom | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Blue Cube Netherlands B.V. – OR1 | Axelsedam 3a 4531HH Terneuzen Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| 3M Belgium BVBA/SPRL | Hermeslaan 7 1831 Diegem Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Trinseo Deutschland Anlagengesellschaft mbH | Kölner Strasse 10 65760 Eschborn Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| SABIC Petrochemicals B.V. | Europaboulevard 1 6135 LD Sittard Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| TÜV SÜD Iberia S.A.U. (051) | Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| T-NET International (EU) GmbH | Rurtal Str. 33 41849 Wassenberg NRW Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| RSI ChemRep Europe Ltd (M001) | 27-30 Merchants Quay Merchants House 8 Dublin Ireland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Du Pont (U.K.) Limited | London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Huntsman Textile Effects (Germany) GmbH | Rehlinger Str. 1 D-86462 Langweid a.Lech Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| RSI ChemRep Europe Ltd (M003) | 27-30 Merchants Quay Merchants House 8 Dublin Ireland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| INEOS Composites Hispania S.L. (0341) | Partida Povet, 37 ES-12580 Benicarlo Castillon de la Plana Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| KTR Europe GmbH | Mergenthalerallee 77 65760 Eschborn Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Du Pont de Nemours (Deutschland) GmbH | Hugenottenallee 173-175 D-63263 Neu-Isenburg Hesse Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| PPG Europe B.V. - OR1 | Amsterdamseweg 14 1422 AD Uithoorn Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Lubrizol Europe Coordination Center BVBA 02 | Chaussee De Wavre 1945 Brussels Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Lubrizol Europe Coordination Center BVBA 01 | Chaussee De Wavre, 1945 1945 Brussels Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Allnex Italy S.R.L. | Via Matteo Bianchin, 62 36060 Romano d'Ezzelino Italy | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Idemitsu Chemicals Europe GmbH | Immermannstrasse 40 40210 Düsseldorf Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Harke Services GmbH-OR3 | Xantener Str.1 45479 Mülheim an der Ruhr Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| RSI ChemRep Europe Ltd (I001) | 27-30 Merchants Quay Merchants House 8 Dublin Ireland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| SI Group-Béthune S.A.S. | 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Solvay Specialty Polymers Italy S.p.A. | Viale Lombardia 20 20021 BOLLATE Italy | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| KIST Europe Forschungsgesellschaft mbH | Campus E 71 Saarbruecken 66123 Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| StonCor Europe | Rue du Travail, 9 1400 Nivelles Belgium | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Blue Cube Germany Assets GmbH & Co. KG | Buetzflether Sand 2 21683 Stade Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Team-Trade, s.r.o. | Rybničná 18/1 16200 Prague Czech Republic | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| PPG Coatings BV | Papesteeg 102 4006 WC Tiel Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Rondo Plast AB | Blygatan 6 27139 Ystad Sweden | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| RSI ChemRep Europe Ltd (M002) | 27-30 Merchants Quay Merchants House 8 Dublin Ireland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| PCC SYNTEZA SA | Szkolna 15 47-225 Kędzierzyn-Koźle opolskie Poland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Hexion B.V. | Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Experien Chemical Services (Europe) Limited | 7 Finkle Street YO7 1DA Thirsk United Kingdom | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Hexion B.V. OR | Seattleweg 17, Building 4 3195 ND Pernis-Rotterdam Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| REACHLaw Ltd. | Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| ENVIGO CRS SAU 155 | Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Spolek pro chemickou a hutní výrobu, a.s. | Revoluční 1930/86 400 32 Ústí nad Labem Czech Republic | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| AKZO Nobel Car Refinishes B.V. | Rijksstraatweg 31 2170 BA Sassenheim Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| SABIC Innovative Plastics Espana ScpA | Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| [Confidential] | [Confidential] | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| SABIC Innovative Plastics BV | Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Axalta Coating Systems Germany GmbH & Co. KG | Christbusch 25 42285 Wuppertal Germany | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| 3M Wroclaw Sp.z.o.o. | ul. Kowalska 143 51-424 Wroclaw Poland | - | - | 4,4'-isopropylidenediphenol | 201-245-8 | 80-05-7 | - | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (+-)-TRANS-3-METHYL-1-[(4-METHYLPHENYL)SULFONYL]-4-PHENYLPIPERIDINE-4-CARBONITRILE | 607-821-9 | 25858-24-6 | 2020 | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (+/-)-[(R*,R*)and(R*,S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran | 419-600-2 | 99199-90-3 | 2017 | View substance registered dossier |
| CHEMICAL INSPECTION & REGULATION SERVICE LIMITED | Regus Harcourt Centre D02 HW77 Dublin Ireland | Ireland | Cease Manufacture | (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate | 425-220-8 | 5945-33-5 | 2014 | View substance registered dossier |
| [Confidential] | - | - | - | (10S)-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide | 810-248-9 | 104746-04-5 | - | View substance registered dossier |
| Minakem Dunkerque Production | 224 avenue de la Dordogne Zone d'entreprises du Nord Gracht 59640 DUNKERQUE France | France | Cease Manufacture | (1E)-N-hydroxy-1-(naphthalen-1-yl)ethanimine | 700-765-7 | 100485-51-6 | 2019 | View substance registered dossier |
| ROQUETTE Frères | 1 rue de la haute loge 62136 LESTREM Cedex France | France | Cease Manufacture | (1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol | 413-110-2 | 135861-56-2 | 2018 | View substance registered dossier |
| Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Cease Manufacture | (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate | 604-569-1 | 147126-62-3 | 2021 | View substance registered dossier |
| Cheminova A/S | Thyborønvej 76-78 DK-7673 Harboøre Denmark | Denmark | Cease Manufacture | (1R,4R,5S)-6,6-dimethyl-4-(tribromomethyl)-3-oxabicyclo[3.1.0]hexan-2-one | 619-738-5 | 87305-03-1 | 2014 | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (1S)-2,3,4,6-TETRA-O-ACETYL-1,5-ANHYDRO-1-(3-{[5-(4-FLUOROPHENYL)THIOPHEN-2-YL]METHYL}-4-METHYLPHENYL)-D-GLUCITOL | 617-901-5 | 866607-35-4 | 2019 | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (1S,2R)-1-((2R,3R,4S,6S)-3-acetamido-4-(diallylamino)-6-hydroxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate | 700-779-3 | - | 2020 | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (1S,3R,4R,5R)-methyl 3-acetoxy-4,5-dihydroxycyclohexanecarboxylate | 839-204-7 | 1104200-21-6 | 2020 | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (1S,3R,4R,5S)-methyl 3-acetoxy-5-azido-4-(((2S,3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)cyclohexanecarboxylate | 813-345-4 | 1104200-23-8 | 2020 | View substance registered dossier |
| Productos Esteve Internacional, S.A | Avd. Verge Montserrat, 12. 08024 Barcelona Barcelona Spain | Spain | Cease Manufacture | (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol hydrochloride | 700-391-4 | 6953-28-2 | 2017 | View substance registered dossier |
| [Confidential] | - | - | - | (2-bromo-5-fluorophenyl)methanol | 606-492-9 | 202865-66-5 | - | View substance registered dossier |
| BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Cease Manufacture | (2-hydroxyethyl)(3-hydroxypropyl)dimethylammonium chloride | 278-860-3 | 78182-00-0 | 2020 | View substance registered dossier |
| Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Kalkstrasse 218 51377 Leverkusen Germany | Germany | Cease Manufacture | (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol | 841-499-2 | 1340593-59-0 | 2020 | View substance registered dossier |
| [Confidential] | - | - | - | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate | 807-677-9 | 817204-32-3 | - | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate | 612-107-5 | 61259-48-1 | 2019 | View substance registered dossier |
| BASF Schwarzheide GmbH | Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany | Germany | Cease Manufacture | (2RS,3RS)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[(1H-1,2,4-triazol-1-yl)methyl]oxirane | 406-850-2 | 133855-98-8 | 2016 | View substance registered dossier |
| Fine Organics Limited | Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom | United Kingdom | No longer Valid | (2RS,3RS)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[(1H-1,2,4-triazol-1-yl)methyl]oxirane | 406-850-2 | 133855-98-8 | 2021 | View substance registered dossier |
| TAMARANG, S.A. | Balmes, 84, 4-2 08008 Barcelona Barcelona Spain | Spain | Cease Manufacture | (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid | 406-310-6 | - | 2012 | View substance registered dossier |
| Avara Shannon Pharmaceutical Services Limited | Shannon Industrial Estate V14 FX09 Shannon Clare Ireland | Ireland | Cease Manufacture | (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1) | 695-797-0 | 93601-86-6 | 2021 | View substance registered dossier |
| Avara Shannon Pharmaceutical Services Limited | Shannon Industrial Estate V14 FX09 Shannon Clare Ireland | Ireland | Cease Manufacture | (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium (2R)-(2-chlorophenyl)(hydroxy)acetate | 814-350-4 | 1352917-66-8 | 2021 | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (2S)-[[(benzyloxy)carbonyl]amino](cyclohexyl)acetic acid | 478-210-0 | 69901-75-3 | 2019 | View substance registered dossier |
| Wacker Chemie AG | Hanns-Seidel-Platz 4 81737 Muenchen Germany | Germany | Cease Manufacture | (2S)-pentan-2-ol | 700-266-4 | 26184-62-3 | 2016 | View substance registered dossier |
| Warsaw University of Technology, Faculty of Chemistry, Laboratory of Technological Processes | Noakowskiego 3 00-664 Warszawa Poland | Poland | Cease Manufacture | (2S,3S)-2,3-Bis((4-methoxybenzoyl)oxy)succinic acid | 606-247-6 | 191605-10-4 | 2014 | View substance registered dossier |
| Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | Cease Manufacture | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2019 | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2019 | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peter Strasse 25 4020 Linz Austria | Austria | Cease Manufacture | (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) | 604-018-5 | 137433-01-3 | 2020 | View substance registered dossier |
| FIS Fabbrica Italiana Sintetici SpA | Viale Milano, 26 36075 Montecchio Maggiore (Vicenza) Italy | Italy | Cease Manufacture | (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) | 604-018-5 | 137433-01-3 | 2015 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | Cease Manufacture | (2α,4aα,8β)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one | 249-648-8 | 29461-13-0 | 2020 | View substance registered dossier |
| Aspen Oss BV | Kloosterstraat 6 5349 AB Oss Netherlands | Netherlands | Cease Manufacture | (3 β, 5 α, 6β)-3-(acetyloxy)-5-bromo-6-hydroxy-androstan-17-one | 419-790-7 | 4229-69-0 | 2019 | View substance registered dossier |
| Saltigo GmbH | HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany | Germany | Cease Manufacture | (3,4-Dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-methylamine | 917-818-7 | 73344-75-9 | 2013 | View substance registered dossier |
| Boehringer Ingelheim Pharma GmbH & Co. KG | Binger Strasse 173 55216 Ingelheim am Rhein Germany | Germany | Cease Manufacture | (3-aminophenyl)pyridin-3-ylmethanone | 428-230-0 | 79568-06-2 | 2015 | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl methanesulfonate | 700-367-3 | 35130-97-3 | 2012 | View substance registered dossier |
| Minakem Dunkerque Production | 224 avenue de la Dordogne Zone d'entreprises du Nord Gracht 59640 DUNKERQUE France | France | Cease Manufacture | (3aR,6S)-8,8-dimethyl-4,5,6,7-tetrahydro-3a,6-methano-2,1-benzothiazole 2,2-dioxide | 621-464-6 | 107869-45-4 | 2019 | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl[(methylsulfonyl)oxy]acetate | 700-396-1 | 60924-38-1 | 2012 | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (3beta)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate compound with (2R,3R)-tartaric acid and methanol (1 : 1 : 1.5) | 931-336-4 | - | 2019 | View substance registered dossier |
| Agfa-Gevaert N.V. | Septestraat 27 2640 Mortsel Belgium | Belgium | Cease Manufacture | (3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde | 801-656-8 | 1416808-92-8 | 2021 | View substance registered dossier |
| Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Cease Manufacture | (3R)-3-(2-amino-2-oxoethyl)-5-methylhexanoic acid | 605-923-8 | 181289-33-8 | 2017 | View substance registered dossier |
| [Confidential] | - | - | - | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-oxime | 603-883-6 | 134931-01-4 | - | View substance registered dossier |
| MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Cease Manufacture | (3R,7aR)-3-tert-butyl-1,5-dioxodihydro-1H-pyrrolo[1,2-c][1,3]oxazole-7a(5H)-carbaldehyde | 812-036-1 | 1214741-19-1 | 2019 | View substance registered dossier |
| MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Cease Manufacture | (3R,7aR)-3-tert-butyl-7a-{methoxy[(trimethylsilyl)oxy]methyl}dihydro-1H-pyrrolo[1,2-c][1,3]oxazole-1,5(6H)-dione | 942-823-6 | - | 2019 | View substance registered dossier |
| MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Cease Manufacture | (3R,7aS)-3-tert-butyldihydro-1H-pyrrolo[1,2-c][1,3]oxazole-1,5(6H)-dione | 810-392-2 | 171284-84-7 | 2019 | View substance registered dossier |
| TÜV SÜD Industrie Service GmbH | IS-USR-MUC Westendstr. 199 80686 Munich Germany | Germany | Cease Manufacture | (3S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one | 626-470-2 | 5405-40-3 | 2015 | View substance registered dossier |
| Roche Ireland Limited | Clarehill . Clarecastle Ireland | Ireland | Cease Manufacture | (3S,4aS,8aS)-2-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide | 430-230-0 | 136522-17-3 | 2020 | View substance registered dossier |
| Roche Ireland Limited | Clarehill . Clarecastle Ireland | Ireland | Cease Manufacture | (3S,4aS,8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide | 420-380-5 | 136465-81-1 | 2020 | View substance registered dossier |
| CU Chemie Uetikon GmbH | Raiffeisenstrasse 4 77933 Lahr Germany | Germany | Cease Manufacture | (3S,5R,8aS)-3-phenylhexahydro-5H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile | 634-598-5 | 106565-71-3 | 2020 | View substance registered dossier |
| Lek Pharmaceuticals d.d. | Verovskova 57 1526 Ljubljana Slovenia | Slovenia | Cease Manufacture | (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone | 610-965-5 | 53123-88-9 | 2017 | View substance registered dossier |
| Santrol Europe ApS | Aagade 103 Pjedsted 7000 Fredericia Denmark | Denmark | Cease Manufacture | (3S-cis)-3,6-dimethyl-1,4-dioxane-2,5-dione | 224-832-0 | 4511-42-6 | 2016 | View substance registered dossier |
| Derivados Quimicos SAU | Strada Rivoltana km6/7 20053 Rodano (Milano) Lombardia Spain | Spain | Cease Manufacture | (4-chloro-2-fluorophenyl)acetonitrile | 642-783-7 | 75279-53-7 | 2020 | View substance registered dossier |
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