Registered substances

Data platform availability banner - registered substances

The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM.  More

Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.


 

DISSEMINATION
PLATFORM

REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



No results were found
Details
(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol [(1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid
948-743-8 - Active Intermediate Joint Intermediate use only 04-10-2018 View substance registered dossier
(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate dihydrochloride
948-534-1 1639208-51-7 Active Intermediate Joint Intermediate use only 20-08-2018 View substance registered dossier
(2R,3R,4R)-3,4-Bis(benzyloxy)-2-((benzyloxy)methyl)-5-methoxytetrahydrofuran
857-987-3 64363-77-5 Active Intermediate Joint Intermediate use only 01-09-2020 View substance registered dossier
(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolane-2-carbonitrile
856-564-0 1355357-49-1 Active Intermediate Joint Intermediate use only 09-07-2020 View substance registered dossier
(2R,3R,4R,5R)-5-(2-Amino-6-chloro-9h-purin-9-yl)-2-[(4-chlorobenzoyloxy)methyl]-4-fluoro-4-methyloxolan-3-yl 4-chlorobenzoate
875-019-8 1294481-82-5 Active Intermediate Joint Intermediate use only 27-10-2021 View substance registered dossier
(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
807-677-9 817204-32-3 Active Intermediate Joint Intermediate use only 08-03-2017 View substance registered dossier
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
857-885-9 1191237-69-0 Active Intermediate Joint Intermediate use only 07-09-2020 View substance registered dossier
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-12,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
927-721-1 - Active Intermediate Joint Intermediate use only 19-06-2020 View substance registered dossier
(2R,3S)-butane-2,3-diol
823-920-1 5341-95-7 Active Full Joint ≥ 10 to < 100 tonnes 15-02-2023 View substance registered dossier
(2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride
425-260-6 244634-31-9 Active Intermediate Joint Intermediate use only 10-04-2012 View substance registered dossier
(2R,3S,4R)-2-(Hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diol
857-672-0 13039-63-9 Active Intermediate Joint Intermediate use only 01-09-2020 View substance registered dossier
(2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl) hexan-1-one
829-550-7 1431329-04-2 Active Intermediate Joint Intermediate use only 05-05-2020 View substance registered dossier
(2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane
433-820-6 118058-74-5 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
616-385-9 76801-85-9 Active Intermediate Joint Intermediate use only 29-03-2019 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-erythro-hexopyranosyl-4-ulose)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 2-O-[(benzyloxy)carbonyl]-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside trifluoroacetate (1:2)
953-335-8 1210740-88-7 Active Intermediate Joint Intermediate use only 30-03-2021 View substance registered dossier
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]oct-6-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 3,4,6-trideoxy-3-(dimethylamino)--D-xylo-hexopyranoside
953-425-7 217500-75-9 Active Intermediate Joint Intermediate use only 28-01-2021 View substance registered dossier
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-((R)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxotan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one
809-911-5 1431329-07-5 Active Intermediate Joint Intermediate use only 17-04-2015 View substance registered dossier
(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl) -4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carboxylic acid: (R )-alfa- methylbenzylamine salt (1:1)
893-589-6 2649470-89-1 Active Intermediate Joint Intermediate use only 25-05-2023 View substance registered dossier
(2RS, 3SR)-3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4- difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride
928-729-8 - Active Intermediate Joint Intermediate use only 24-04-2013 View substance registered dossier
(2RS,3SR)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulphonate
917-473-2 - Active Intermediate Joint Intermediate use only 16-04-2013 View substance registered dossier
(2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane 406-850-2 133855-98-8 Active Full Joint ≥ 100 to < 1 000 tonnes 06-05-2022 View substance registered dossier
(2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
682-862-3 78715-23-8 No longer Valid Intermediate Joint No longer valid 12-04-2018 View substance registered dossier
(2S)-1,1,2-triphenylethane-1,2-diol
624-788-6 108998-83-0 Active Intermediate Joint Intermediate use only 14-06-2018 View substance registered dossier
(2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride
953-783-4 2171323-89-8 Active Intermediate Joint Intermediate use only 24-06-2022 View substance registered dossier
(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
214-494-2 1135-66-6 Active Full Joint ≥ 1 to < 10 tonnes 16-01-2019 View substance registered dossier
(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
214-494-2 1135-66-6 Active Intermediate Joint Intermediate use only 07-01-2020 View substance registered dossier
(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
807-388-8 207557-35-5 Active Intermediate Joint Intermediate use only 11-11-2022 View substance registered dossier
(2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid
928-037-6 2752-38-7 Active Intermediate Joint Intermediate use only 26-01-2018 View substance registered dossier
(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
617-556-0 84348-37-8 Active Intermediate Joint Intermediate use only 03-08-2022 View substance registered dossier
(2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid
832-934-7 869001-86-5 Active Intermediate Joint Intermediate use only 18-03-2022 View substance registered dossier
(2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid
813-635-0 103336-06-7 Active Intermediate Joint Intermediate use only 07-12-2018 View substance registered dossier
(2S)-1-amino-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-aminium chloride
954-882-5 2628280-48-6 Active Intermediate Joint Intermediate use only 16-03-2022 View substance registered dossier
(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
608-945-6 340-90-9 Active Full Joint ≥ 10 to < 100 tonnes 21-02-2023 View substance registered dossier
(2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid
443-560-5 88784-33-2 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol
605-429-2 16614-60-1 Active Intermediate Joint Intermediate use only 26-03-2019 View substance registered dossier
(2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5)
610-316-6 467426-34-2 Active Intermediate Joint Intermediate use only 11-08-2017 View substance registered dossier
(2S)-2-(3-benzoylphenyl)propanoic acid
606-944-5 22161-81-5 Active Intermediate Joint Intermediate use only 06-11-2019 View substance registered dossier
(2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol
605-274-0 16196-70-6 Active Intermediate Joint Intermediate use only 08-06-2018 View substance registered dossier
(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
431-620-3 - Active Full Joint ≥ 10 to < 100 tonnes 16-05-2017 View substance registered dossier
(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
431-620-3 - Active Full Joint ≥ 10 tonnes 15-02-2012 View substance registered dossier
(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
431-620-3 - Active Intermediate Joint Intermediate use only 19-12-2016 View substance registered dossier
(2S)-2-[(4-Chlorobenzoyl)oxy]propanoic acid
817-559-9 1047975-16-5 Active Intermediate Joint Intermediate use only 20-12-2017 View substance registered dossier
(2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanal
861-038-9 3986-89-8 Active Intermediate Joint Intermediate use only 02-12-2020 View substance registered dossier
(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid
616-135-9 74761-42-5 Active Intermediate Joint Intermediate use only 17-04-2020 View substance registered dossier
(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid
406-310-6 - Active Intermediate Joint Intermediate use only 26-02-2020 View substance registered dossier
(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid
406-310-6 - Active Intermediate Joint Intermediate use only 28-01-2019 View substance registered dossier
(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid
617-393-5 82834-12-6 Active Intermediate Joint Intermediate use only 24-11-2021 View substance registered dossier
(2S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid;hydrochloride
611-205-5 5486-79-3 Active Intermediate Joint Intermediate use only 12-09-2019 View substance registered dossier
(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid
891-585-9 21820-51-9 Active Intermediate Joint Intermediate use only 04-04-2023 View substance registered dossier
(2S)-2-amino-3-(4-{[bis(sodiooxy)phosphoryl]oxy}phenyl)propanoic acid
860-352-3 1610350-91-8 Active Full Joint ≥ 10 to < 100 tonnes 30-06-2023 View substance registered dossier
No results were found
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol [(1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid 948-743-8 - - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate dihydrochloride 948-534-1 1639208-51-7 - View substance registered dossier
PCAS 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France France Active (2R,3R,4R)-3,4-Bis(benzyloxy)-2-((benzyloxy)methyl)-5-methoxytetrahydrofuran 857-987-3 64363-77-5 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolane-2-carbonitrile 856-564-0 1355357-49-1 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3R,4R,5R)-5-(2-Amino-6-chloro-9h-purin-9-yl)-2-[(4-chlorobenzoyloxy)methyl]-4-fluoro-4-methyloxolan-3-yl 4-chlorobenzoate 875-019-8 1294481-82-5 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 807-677-9 817204-32-3 - View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile 857-885-9 1191237-69-0 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-12,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate 927-721-1 - 2013 View substance registered dossier
Upjohn Manufacturing Ireland Unlimited Little Island T45 F627 Co. Cork Ireland Ireland Active (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-12,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate 927-721-1 - - View substance registered dossier
SCC Scientific Consulting Company GmbH Am Grenzgraben 11 55545 Bad Kreuznach Germany Germany Active (2R,3S)-butane-2,3-diol 823-920-1 5341-95-7 2023 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride 425-260-6 244634-31-9 - View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Cease Manufacture (2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride 425-260-6 244634-31-9 2020 View substance registered dossier
PCAS 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France France Active (2R,3S,4R)-2-(Hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diol 857-672-0 13039-63-9 - View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl) hexan-1-one 829-550-7 1431329-04-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 433-820-6 118058-74-5 - View substance registered dossier
Sanofi Aventis Deutschland GmbH Industriepark Höchst H 831 (Room A0472) z.Hd. Hr. Dr. Schwind 65926 Frankfurt am Main Germany Germany Active (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 433-820-6 118058-74-5 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-((4-Dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy)-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 433-820-6 118058-74-5 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
Midas Pharma GmbH Rheinstrasse 49 55218 Ingelheim Germany Germany Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
Ercros SA Avenida Diagonal 593-595 08014 Barcelona Spain Spain Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one 616-385-9 76801-85-9 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-erythro-hexopyranosyl-4-ulose)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 2-O-[(benzyloxy)carbonyl]-3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside trifluoroacetate (1:2) 953-335-8 1210740-88-7 2021 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]oct-6-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl 3,4,6-trideoxy-3-(dimethylamino)--D-xylo-hexopyranoside 953-425-7 217500-75-9 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2R,3S,4S)-2,3,4-tris(benzyloxy)-4-((R)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxotan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one 809-911-5 1431329-07-5 - View substance registered dossier
Derivados Químicos S.A. Camino de Pliego, 150 30820 Alcantarilla Murcia Spain Spain Active (2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl) -4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carboxylic acid: (R )-alfa- methylbenzylamine salt (1:1) 893-589-6 2649470-89-1 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2RS, 3SR)-3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4- difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride 928-729-8 - 2013 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X336 Ringaskiddy Cork Ireland Ireland Active (2RS,3SR)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulphonate 917-473-2 - 2011; 2013 View substance registered dossier
BASF Schwarzheide GmbH Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany Germany Active (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane 406-850-2 133855-98-8 2022 View substance registered dossier
Macfarlan Smith Limited Wheatfield Road EH11 2QA Edinburgh United Kingdom United Kingdom No longer Valid (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol 682-862-3 78715-23-8 2021 View substance registered dossier
UNION QUIMICO FARMACÉUTICA S.A. Mallorca 262 08008 Barcelona Barcelona Spain Spain Active (2S)-1,1,2-triphenylethane-1,2-diol 624-788-6 108998-83-0 - View substance registered dossier
Corteva Agriscience Spain, S.L.U Valle de Tamón s/n 33469 Carreño (Asturias) Spain 33469 Carreño (Asturias) Spain Spain Active (2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride 953-783-4 2171323-89-8 - View substance registered dossier
EcoGreen Fine Chemicals B.V. Lichtenauerlaan 102-120 3062ME Rotterdam Netherlands Netherlands Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2018 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2019 View substance registered dossier
REACH24H CONSULTING GROUP Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland Ireland Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2020 View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 - View substance registered dossier
JSC "Olainfarm" Rupnicu str. 5 LV-2114 Olaine Latvia Latvia Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 2019 View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 - View substance registered dossier
MOEHS BCN, S.L. C/ Zenc, 12 08755 Castellbisbal Barcelona Spain Spain Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active (2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid 928-037-6 2752-38-7 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 617-556-0 84348-37-8 2020; 2022 View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 617-556-0 84348-37-8 - View substance registered dossier
Corden Pharma Bergamo S.p.A. Via Bergamo, 121 IT-24047 Treviglio BG Italy Italy Active (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid 832-934-7 869001-86-5 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid 832-934-7 869001-86-5 - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid 813-635-0 103336-06-7 - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid 813-635-0 103336-06-7 - View substance registered dossier
[Confidential] - - - (2S)-1-amino-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-aminium chloride 954-882-5 2628280-48-6 - View substance registered dossier
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany Germany Active (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID 608-945-6 340-90-9 2019; 2022 View substance registered dossier
SIGMA-ALDRICH CHEMIE GMBH Riedstrasse 2 89555 Steinheim Germany Germany Active (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID 608-945-6 340-90-9 - View substance registered dossier
ISOCHEM 32 rue Lavoisier 91710 VERT LE PETIT France France Active (2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid 443-560-5 88784-33-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - No longer Valid (2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid 443-560-5 88784-33-2 2022 View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-429-2 16614-60-1 2019 View substance registered dossier
Macfarlan Smith Limited Wheatfield Road EH11 2QA Edinburgh United Kingdom United Kingdom No longer Valid (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-429-2 16614-60-1 2021 View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active (2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5) 610-316-6 467426-34-2 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5) 610-316-6 467426-34-2 2017 View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-2-(3-benzoylphenyl)propanoic acid 606-944-5 22161-81-5 2019 View substance registered dossier
LusoChimica S.p.A. Via Giotto, 9 23871 Lomagna (Lecco) Italy Italy Active (2S)-2-(3-benzoylphenyl)propanoic acid 606-944-5 22161-81-5 - View substance registered dossier
Lodichem S.r.l. Via delle Rimembranze, 1 26582 Mairano di Casaletto Lodigiano (Lodi) Italy Italy Active (2S)-2-(3-benzoylphenyl)propanoic acid 606-944-5 22161-81-5 - View substance registered dossier
Macfarlan Smith Limited Wheatfield Road EH11 2QA Edinburgh United Kingdom United Kingdom No longer Valid (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-274-0 16196-70-6 2021 View substance registered dossier
Alkaloida Chemical Company Zrt. Kabay Janos 29 H-4440 Tiszavasvari Hungary Hungary Active (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-274-0 16196-70-6 2018 View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active (2S)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-274-0 16196-70-6 - View substance registered dossier
Swords Laboratories Unlimited Company Cruiserath Road Mulhuddart D15H6EF Dublin 15 Co Dublin Ireland Ireland Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - 2009; 2010; 2017 View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Cease Manufacture (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - 2022 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - - View substance registered dossier
Evonik Rexim S.A.S. 33, Rue de Verdun 80400 Ham France France Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - 2011 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - 2012 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Active (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 431-620-3 - - View substance registered dossier
A.C.R.A.F. Spa Via Amelia 70 00181 Roma Italy Italy Active (2S)-2-[(4-Chlorobenzoyl)oxy]propanoic acid 817-559-9 1047975-16-5 - View substance registered dossier
CHEMO BIOSYNTHESIS SRL VIALE ISONZO, 8 20135 MILANO Italy Italy Active (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanal 861-038-9 3986-89-8 - View substance registered dossier
Flamma S.p.a. via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy Italy Active (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid 616-135-9 74761-42-5 2019 View substance registered dossier
Gilead Sciences Ireland UC IDA Business &Technology Park Carrigtohill Cork Cork Ireland Ireland Active (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid 616-135-9 74761-42-5 - View substance registered dossier
MSD International GmbH (Ballydine Branch) Ballydine - Kilsheelan 0 Clonmel Ireland Ireland Active (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoic acid 616-135-9 74761-42-5 - View substance registered dossier
Huvepharma Italia s.r.l. Via Roberto Lepetit, 142 12075 GARESSIO (CN) Italy Italy Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - 2010; 2012 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - - View substance registered dossier
MAPIC Europe NV EXCELSIORLAAN 83 1930 ZAVENTEM Belgium Belgium Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. - - Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - - View substance registered dossier
B.I.G. - OR634 Technische Schoolstraat 43A 2440 Geel Belgium Belgium Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - 2011; 2012; 2014; 2020 View substance registered dossier
EUROAPI Germany GmbH Brüningstraße 50 65926 Frankfurt am Main Germany Germany Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - 2010; 2012 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - - View substance registered dossier
Saltigo GmbH HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany Germany Cease Manufacture (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - 2014 View substance registered dossier
EGIS Pharmaceuticals PLC Keresztúri út 30-38 H-1106 Budapest Hungary Hungary Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - - View substance registered dossier
Medichem S.A. Polígon Industrial de Celrà 17460 Celrà Girona Spain Spain Active (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 - 2018 View substance registered dossier
ROLABO OUTSOURCING, S.L. Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain Spain Active (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid 617-393-5 82834-12-6 - View substance registered dossier
LABORATORIOS SERVIER S.L. RIO JARAMA 59 45007 TOLEDO Spain Spain Active (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid 617-393-5 82834-12-6 - View substance registered dossier
ORIL INDUSTRIE 13 rue Auguste Desgenétais 76210 BOLBEC France France Active (2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid 617-393-5 82834-12-6 2019; 2020; 2021 View substance registered dossier
Midas Pharma Polska Sp. z o.o. Ul. Hankiewicza 2 02-103 Warszawa Poland Poland Active (2S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid;hydrochloride 611-205-5 5486-79-3 - View substance registered dossier
EGIS Pharmaceuticals PLC Keresztúri út 30-38 H-1106 Budapest Hungary Hungary Active (2S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid;hydrochloride 611-205-5 5486-79-3 - View substance registered dossier
Arevipharma GmbH Meißner Straße 35 01445 Radebeul Saxony Germany Germany Active (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 891-585-9 21820-51-9 - View substance registered dossier
Sigma-Aldrich Ireland Ltd Vale Road . Arklow Co. Wicklow Ireland Ireland Active (2S)-2-amino-3-(4-{[bis(sodiooxy)phosphoryl]oxy}phenyl)propanoic acid 860-352-3 1610350-91-8 - View substance registered dossier
Arevipharma GmbH Meißner Straße 35 01445 Radebeul Saxony Germany Germany Active (2S)-2-amino-3-(4-{[bis(sodiooxy)phosphoryl]oxy}phenyl)propanoic acid 860-352-3 1610350-91-8 - View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.