Registered substances

Registered substances

Registered substances

Please note:

As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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Details
(+)-2-amino-1-butanol
227-475-9 5856-62-2 Cease Manufacture Intermediate Joint Cease manufacture 10-04-2017 View substance registered dossier
(+-)-2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
607-685-0 252964-68-4 Cease Manufacture Full Joint Cease manufacture 29-05-2018 View substance registered dossier
(+/-) tetrahydrofurfuryl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate
PANTERA; QUIZALOFOP-P-TEFURYL
414-200-4 200509-41-7 Cease Manufacture NONS Joint Cease manufacture 15-12-2008 View substance registered dossier
(+/-)-[(R*,R*)and(R*,S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
T001446
419-600-2 99199-90-3 Cease Manufacture NONS Individual Cease manufacture 12-09-2012 View substance registered dossier
(1-chlorocyclohexyl) cyclohexyl ketone
280-893-3 83803-75-2 Cease Manufacture Intermediate Joint Cease manufacture 08-06-2016 View substance registered dossier
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
425-220-8 5945-33-5 Cease Manufacture Full Individual Cease manufacture 20-11-2012 View substance registered dossier
(10aS)-methyl 10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate
607-239-5 23495-64-9 Cease Manufacture Full Joint Cease manufacture 28-05-2018 View substance registered dossier
(17α)-17-hydroxy-3-oxoandrost-4-ene-17-carbonitrile
278-780-9 77881-13-1 Cease Manufacture Intermediate Joint Cease manufacture 22-10-2012 View substance registered dossier
(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
413-110-2 135861-56-2 Cease Manufacture Full Individual Cease manufacture 02-04-2013 View substance registered dossier
(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
413-110-2 135861-56-2 Cease Manufacture Full Individual Cease manufacture 17-08-2012 View substance registered dossier
(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
413-110-2 135861-56-2 Cease Manufacture Full Individual Cease manufacture 21-05-2013 View substance registered dossier
(1R,2S,3S,4R)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid
821-184-6 1777721-60-4 Cease Manufacture Full Joint Cease manufacture 28-02-2019 View substance registered dossier
(1R,2S,3S,4R)-3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic
821-185-1 1777721-63-7 Cease Manufacture Full Joint Cease manufacture 28-02-2019 View substance registered dossier
(1R,3S,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine fumarate
943-085-8 - Cease Manufacture Intermediate Individual Cease manufacture 04-04-2016 View substance registered dossier
(1S)-1-cyclopropylethanamine; (2R)-2-hydroxy-2-phenyl-acetic acid
946-290-0 2246580-61-8 Cease Manufacture Intermediate Joint Cease manufacture 01-10-2020 View substance registered dossier
(1S,3R,4R,5R)-methyl 3-acetoxy-4,5-dihydroxycyclohexanecarboxylate
839-204-7 1104200-21-6 Cease Manufacture Intermediate Individual Cease manufacture 03-06-2019 View substance registered dossier
(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol hydrochloride
700-391-4 6953-28-2 Cease Manufacture Intermediate Individual Cease manufacture 02-12-2010 View substance registered dossier
(2-hydroxyethyl)(3-hydroxypropyl)dimethylammonium chloride
278-860-3 78182-00-0 Cease Manufacture Intermediate Individual Cease manufacture 30-08-2011 View substance registered dossier
(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}-3-(1H-tetrazol-1-yl)propan-2-ol
841-499-2 1340593-59-0 Cease Manufacture Full Joint Cease manufacture 25-08-2020 View substance registered dossier
(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid
406-310-6 82717-96-2 Cease Manufacture Intermediate Individual Cease manufacture 22-11-2011 View substance registered dossier
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)
695-797-0 93601-86-6 Cease Manufacture Full Joint Cease manufacture 04-07-2018 View substance registered dossier
(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium (2R)-(2-chlorophenyl)(hydroxy)acetate
814-350-4 1352917-66-8 Cease Manufacture Full Joint Cease manufacture 04-07-2018 View substance registered dossier
(2S,3R,4R,5S,6R)-3,4,5-tris(benzyloxy)-2-methyl-6-(p-tolylthio)tetrahydro-2H-pyran
835-228-7 211801-54-6 Cease Manufacture Intermediate Individual Cease manufacture 05-03-2019 View substance registered dossier
(2α,4aα,8β)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one
249-648-8 29461-13-0 Cease Manufacture Full Joint Cease manufacture 24-12-2019 View substance registered dossier
(3 β, 5 α, 6β)-3-(acetyloxy)-5-bromo-6-hydroxy-androstan-17-one
17-KETOBROMOHYDRINE
419-790-7 4229-69-0 Cease Manufacture NONS Individual Cease manufacture 10-11-2008 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Sicor - Società Italiana Corticosteroidi S.r.l. Piazzale Luigi Cadorna 4 20123 Milano (MI) Italy Italy Cease Manufacture (+)-2-amino-1-butanol 227-475-9 5856-62-2 2022 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (+-)-2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 607-685-0 252964-68-4 2021 View substance registered dossier
ESIM Chemicals GmbH St.-Peter-Strasse 25 4020 Linz Austria Austria Cease Manufacture (+/-) tetrahydrofurfuryl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate 414-200-4 200509-41-7 2022 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - No longer Valid (+/-) tetrahydrofurfuryl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate 414-200-4 200509-41-7 2022 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (+/-)-[(R*,R*)and(R*,S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 419-600-2 99199-90-3 2017 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Cease Manufacture (1-chlorocyclohexyl) cyclohexyl ketone 280-893-3 83803-75-2 2022 View substance registered dossier
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Regus Harcourt Centre D02 HW77 Dublin Ireland Ireland Cease Manufacture (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate 425-220-8 5945-33-5 2014 View substance registered dossier
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy Italy Cease Manufacture (10aS)-methyl 10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate 607-239-5 23495-64-9 2022 View substance registered dossier
Bayer AG Kaiser-Wilhelm-Allee 51373 Leverkusen Germany Germany Cease Manufacture (17α)-17-hydroxy-3-oxoandrost-4-ene-17-carbonitrile 278-780-9 77881-13-1 2022 View substance registered dossier
ROQUETTE Frères 1 rue de la haute loge 62136 LESTREM Cedex France France Cease Manufacture (1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol 413-110-2 135861-56-2 2018 View substance registered dossier
REACH COMPLIANCE SERVICES LIMITED Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland Ireland Cease Manufacture (1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol 413-110-2 135861-56-2 2021 View substance registered dossier
REACH24H CONSULTING GROUP Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland Ireland Cease Manufacture (1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol 413-110-2 135861-56-2 2021 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (1R,2S,3S,4R)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid 821-184-6 1777721-60-4 2022 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Cease Manufacture (1R,2S,3S,4R)-3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic 821-185-1 1777721-63-7 2022 View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Cease Manufacture (1R,3S,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine fumarate 943-085-8 - 2021 View substance registered dossier
Bidachem S.p.A. S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy Italy Cease Manufacture (1S)-1-cyclopropylethanamine; (2R)-2-hydroxy-2-phenyl-acetic acid 946-290-0 2246580-61-8 2022 View substance registered dossier
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173 55216 Ingelheim am Rhein Germany Germany Cease Manufacture (1S)-1-cyclopropylethanamine; (2R)-2-hydroxy-2-phenyl-acetic acid 946-290-0 2246580-61-8 2022 View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Cease Manufacture (1S,3R,4R,5R)-methyl 3-acetoxy-4,5-dihydroxycyclohexanecarboxylate 839-204-7 1104200-21-6 2020 View substance registered dossier
Productos Esteve Internacional, S.A Avd. Verge Montserrat, 12. 08024 Barcelona Barcelona Spain Spain Cease Manufacture (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol hydrochloride 700-391-4 6953-28-2 2017 View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Cease Manufacture (2-hydroxyethyl)(3-hydroxypropyl)dimethylammonium chloride 278-860-3 78182-00-0 2020 View substance registered dossier
Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Kalkstrasse 218 51377 Leverkusen Germany Germany Cease Manufacture (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}-3-(1H-tetrazol-1-yl)propan-2-ol 841-499-2 1340593-59-0 2022 View substance registered dossier
TAMARANG, S.A. Balmes, 84, 4-2 08008 Barcelona Barcelona Spain Spain Cease Manufacture (2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid 406-310-6 82717-96-2 2012 View substance registered dossier
Avara Shannon Pharmaceutical Services Limited Shannon Industrial Estate V14 FX09 Shannon Clare Ireland Ireland Cease Manufacture (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1) 695-797-0 93601-86-6 2021 View substance registered dossier
Avara Shannon Pharmaceutical Services Limited Shannon Industrial Estate V14 FX09 Shannon Clare Ireland Ireland Cease Manufacture (2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium (2R)-(2-chlorophenyl)(hydroxy)acetate 814-350-4 1352917-66-8 2021 View substance registered dossier
N.V. Ajinomoto OmniChem S.A. Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium Belgium Cease Manufacture (2S,3R,4R,5S,6R)-3,4,5-tris(benzyloxy)-2-methyl-6-(p-tolylthio)tetrahydro-2H-pyran 835-228-7 211801-54-6 2021 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Cease Manufacture (2α,4aα,8β)-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8(5H)-one 249-648-8 29461-13-0 2020 View substance registered dossier
Aspen Oss BV Kloosterstraat 6 5349 AB Oss Netherlands Netherlands Cease Manufacture (3 β, 5 α, 6β)-3-(acetyloxy)-5-bromo-6-hydroxy-androstan-17-one 419-790-7 4229-69-0 2019 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

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