Registered substances

Registered substances

Registered substances

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.

Please note:
  • The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
  • Please be aware that the annual IUCLID format change is coming soon. We will be adapting the Dissemination platform to the new format, which means that as of 15th October 2021 until early 2022 there will be a break in publication of newly submitted registration dossiers. We appreciate your understanding in this matter.
Last updated 13 October 2021. Database contains 23445 unique substances and contains information from 104978 dossiers.
Substance identity
Administrative data
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First published date:
Last update date:
Substance data
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Uses and exposure
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Details
Ethyl 1,3-dihydro-1,3-dioxo-2H-isoindole-2-carboxylate
245-048-5 22509-74-6 Active Full Joint ≥ 1 to < 10 tonnes 03-03-2017 View substance registered dossier
Ethyl (Z)-docos-13-enoate
253-712-0 37910-77-3 Active Intermediate Individual Intermediate use only 26-09-2017 View substance registered dossier
Ethyl (S)-2-hydroxypropionate
211-694-1 687-47-8 Active Full Joint ≥ 1 000 to < 10 000 tonnes 17-01-2021 View substance registered dossier
Ethyl (E)-4-methylpent-2-enoate
811-774-1 15790-86-0 Active Intermediate Joint Intermediate use only 23-05-2017 View substance registered dossier
ethyl (5-chloro-2-methylphenyl)carbamate
667-167-5 35442-34-3 Active Intermediate Individual Intermediate use only 03-12-2015 View substance registered dossier
ethyl (5-chloro-2-methyl-4-sulfamoylphenyl)carbamate
811-297-9 35442-35-4 Active Intermediate Individual Intermediate use only 03-12-2015 View substance registered dossier
Ethyl (4-methylphenoxy)acetate
266-554-2 67028-40-4 Active Intermediate Joint Intermediate use only 20-07-2018 View substance registered dossier
Ethyl (4-chlorophenyl)acetate
237-906-2 14062-24-9 Active Intermediate Joint Intermediate use only 18-06-2020 View substance registered dossier
ethyl (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
691-244-2 106939-34-8 Active Intermediate Individual Intermediate use only 12-06-2014 View substance registered dossier
Ethyl (3R,4S,5R)-5-azido-3-(1-ethylpropoxy)-4-hydroxycyclohex-1-ene-1-carboxylate
805-633-3 204254-98-8 Active Intermediate Joint Intermediate use only 25-05-2018 View substance registered dossier
ethyl (3R)-4-cyano-3-hydroxybutanoate
430-220-6 141942-85-0 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
ethyl (3R)-3-hydroxybutanoate
695-003-2 24915-95-5 No longer Valid Intermediate Joint No longer valid 13-12-2018 View substance registered dossier
ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate
429-680-0 122665-86-5 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
ethyl (3-benzoyl-2,4,6-trimethylbenzoyl)phenylphosphinate
806-801-9 1539267-56-5 Active Full Joint ≥ 0 to < 10 tonnes 18-02-2021 View substance registered dossier
ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
801-277-8 507448-65-9 No longer Valid Intermediate Individual No longer valid 28-08-2013 View substance registered dossier
ethyl (2Z)-2-[(4-chlorophenyl)hydrazono]-3-(2,6-dichlorophenyl)-3-oxopropanoate
609-702-7 395068-96-9 Cease Manufacture Intermediate Joint Cease manufacture 04-09-2017 View substance registered dossier
ethyl (2S,3S)-3-[(2-chloro-5-fluoro-4-pyrimidinyl)amino]bicyclo[2.2.2]octane-2-carboxylate
821-183-0 1777721-57-9 Active Full Joint ≥ 1 to < 10 tonnes 28-02-2019 View substance registered dossier
Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]pentanoate
700-226-6 488097-90-1 Cease Manufacture Intermediate Individual Cease manufacture 16-03-2011 View substance registered dossier
ETHYL (2R,3AR,10Z,11AS,12AR,14AR)-2-({7-METHOXY-8-METHYL-2-[4-(PROPAN-2-YL)-1,3-THIAZOL-2-YL]QUINOLIN-4-YL}OXY)-5-METHYL-4,14-DIOXO-2,3,3A,4,5,6,7,8,9,11A,12,13,14,14A-TETRADECAHYDROCYCLOPENTA[C]CYCLOPROPA[G][1,6]DIAZACYCLOTETRADECINE-12A(1H)-CARBOXYLATE
618-843-3 923604-57-3 Active Full Joint ≥ 1 to < 10 tonnes 08-08-2017 View substance registered dossier
Ethyl (2R)-2-(methylsulfonyloxy)-4-phenylbutyrate
603-326-7 129277-08-3 Active Intermediate Joint Intermediate use only 28-05-2018 View substance registered dossier
Ethyl (2E,4Z)-2,4-decadienoate
221-178-8 3025-30-7 Active Full Joint ≥ 1 to < 10 tonnes 07-04-2020 View substance registered dossier
ethyl (2E)-4-(dimethylamino)but-2-enoate (2Z)-but-2-enedioic acid (1:1)
941-772-7 - Active Intermediate Joint Intermediate use only 02-06-2015 View substance registered dossier
ethyl (2E)-3-(cyclopropylamino)-2-[(2,4-dichloro-3-methylphenyl)carbonyl]prop-2-enoate
953-808-9 - Active Full Joint ≥ 1 to < 10 tonnes 28-07-2021 View substance registered dossier
Ethyl (2-acetylamino-5-fluoro-4-isothiocyanatophenoxy)acetate
ZK 145720
414-210-9 147379-38-2 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
ethyl (1S,5R,6S)-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate
429-020-1 204254-96-6 Active NONS Joint Tonnage data confidential 21-10-2019 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany Germany Active Ethyl 1,3-dihydro-1,3-dioxo-2H-isoindole-2-carboxylate 245-048-5 22509-74-6 - View substance registered dossier
Croda EU B.V. (OR8) Buurtje 1 2802 BE Gouda Netherlands Netherlands Active Ethyl (Z)-docos-13-enoate 253-712-0 37910-77-3 - View substance registered dossier
CMC Materials Italia S.r.l. (OR) VIA UMBRIA 4 20098 SAN GIULIANO MILANESE Italy Italy Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 - View substance registered dossier
Du Pont de Nemours (Deutschland) GmbH Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany Germany Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 - View substance registered dossier
Intertek Deutschland GmbH 33 Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany Germany Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 - View substance registered dossier
Galactic Place d'Escanaffles 23 7760 Escanaffles Belgium Belgium Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 - View substance registered dossier
PURAC Biochem Arkelsedijk 46 4206AC Gorinchem Netherlands Netherlands Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 2013; 2014; 2015 View substance registered dossier
Chementors Oy Smart Chemistry Park Raisionkaari 55 21200 Raisio Finland Finland Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 2021 View substance registered dossier
SPECIALTY ELECTRONIC MATERIALS UK LIMITED Diamond House Lotus Park Kingsbury Crescent Middx UB7 0DQ Staines Middx United Kingdom United Kingdom No longer Valid Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 2021 View substance registered dossier
JSR Micro n.v. Technologielaan 8 3001 Leuven Belgium Belgium Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 - View substance registered dossier
SIGMA-ALDRICH CHEMIE GMBH Riedstrasse 2 89555 Steinheim Germany Germany Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 2021 View substance registered dossier
Merck Performance Materials GmbH Rheingaustrasse 190-196 65203 Wiesbaden Germany Germany Active Ethyl (S)-2-hydroxypropionate 211-694-1 687-47-8 - View substance registered dossier
Givaudan Iberica SA Pla d'en Batlle s/n 08470 San Celoni Barcelona Spain Spain Active Ethyl (E)-4-methylpent-2-enoate 811-774-1 15790-86-0 - View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active ethyl (5-chloro-2-methylphenyl)carbamate 667-167-5 35442-34-3 - View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active ethyl (5-chloro-2-methyl-4-sulfamoylphenyl)carbamate 811-297-9 35442-35-4 - View substance registered dossier
SYNAROME SA 34 rue Gutenberg 91070 BONDOUFLE France France Active Ethyl (4-methylphenoxy)acetate 266-554-2 67028-40-4 - View substance registered dossier
REACH24H CONSULTING GROUP Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland Ireland Active Ethyl (4-methylphenoxy)acetate 266-554-2 67028-40-4 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active Ethyl (4-chlorophenyl)acetate 237-906-2 14062-24-9 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active ethyl (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 691-244-2 106939-34-8 2014 View substance registered dossier
Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Kalkstrasse 218 51377 Leverkusen Germany Germany Active Ethyl (3R,4S,5R)-5-azido-3-(1-ethylpropoxy)-4-hydroxycyclohex-1-ene-1-carboxylate 805-633-3 204254-98-8 - View substance registered dossier
Borregaard AS Hjalmar Wessels vei 6 1701 Sarpsborg Norway Norway Active ethyl (3R)-4-cyano-3-hydroxybutanoate 430-220-6 141942-85-0 - View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active ethyl (3R)-4-cyano-3-hydroxybutanoate 430-220-6 141942-85-0 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active ethyl (3R)-4-cyano-3-hydroxybutanoate 430-220-6 141942-85-0 - View substance registered dossier
MINAKEM Beuvry Production SAS 145, Chemin des Lilas 59310 Beuvry-la-Forêt France France Cease Manufacture ethyl (3R)-4-cyano-3-hydroxybutanoate 430-220-6 141942-85-0 2015 View substance registered dossier
Bakhu Pharma Ltd 34 Thursby Road Croft Business Park CH62 3PW Bromborough Wirral United Kingdom United Kingdom No longer Valid ethyl (3R)-4-cyano-3-hydroxybutanoate 430-220-6 141942-85-0 2021 View substance registered dossier
TDeltaS Limited University of Oxford Department of Physiology, Anatomy & Genetics Sherrington Building, Parks Road OX1 3PT Oxford United Kingdom United Kingdom No longer Valid ethyl (3R)-3-hydroxybutanoate 695-003-2 24915-95-5 2021 View substance registered dossier
Pfizer Ireland Pharmaceuticals n/a P43 X3336 Ringaskiddy Cork Ireland Ireland Active ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate 429-680-0 122665-86-5 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. - - Active ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate 429-680-0 122665-86-5 - View substance registered dossier
ARKEMA FRANCE 420 rue d'Estienne d'Orves 92700 COLOMBES France France Active ethyl (3-benzoyl-2,4,6-trimethylbenzoyl)phenylphosphinate 806-801-9 1539267-56-5 2021 View substance registered dossier
Fine Organics Limited Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom United Kingdom No longer Valid ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate 801-277-8 507448-65-9 2021 View substance registered dossier
Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Kalkstrasse 218 51377 Leverkusen Germany Germany Cease Manufacture ethyl (2Z)-2-[(4-chlorophenyl)hydrazono]-3-(2,6-dichlorophenyl)-3-oxopropanoate 609-702-7 395068-96-9 2018 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active ethyl (2S,3S)-3-[(2-chloro-5-fluoro-4-pyrimidinyl)amino]bicyclo[2.2.2]octane-2-carboxylate 821-183-0 1777721-57-9 - View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Cease Manufacture Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]pentanoate 700-226-6 488097-90-1 2017 View substance registered dossier
Janssen Pharmaceutica N.V. Turnhoutseweg 30 2340 Beerse Belgium Belgium Active ETHYL (2R,3AR,10Z,11AS,12AR,14AR)-2-({7-METHOXY-8-METHYL-2-[4-(PROPAN-2-YL)-1,3-THIAZOL-2-YL]QUINOLIN-4-YL}OXY)-5-METHYL-4,14-DIOXO-2,3,3A,4,5,6,7,8,9,11A,12,13,14,14A-TETRADECAHYDROCYCLOPENTA[C]CYCLOPROPA[G][1,6]DIAZACYCLOTETRADECINE-12A(1H)-CARBOXYLATE 618-843-3 923604-57-3 - View substance registered dossier
ROLABO OUTSOURCING, S.L. Polígono Industrial Malpica. Calle J, nº 3-4 50016 Zaragoza Zaragoza Spain Spain Active Ethyl (2R)-2-(methylsulfonyloxy)-4-phenylbutyrate 603-326-7 129277-08-3 - View substance registered dossier
CEHTRA Europe S.à.r.l.02 20, Avenue Pasteur L-2310 - Luxembourg Luxembourg Active Ethyl (2E,4Z)-2,4-decadienoate 221-178-8 3025-30-7 2018; 2020 View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active ethyl (2E)-4-(dimethylamino)but-2-enoate (2Z)-but-2-enedioic acid (1:1) 941-772-7 - 2015 View substance registered dossier
INFAR S.A. Ctra N-II Km. 680, 6 08389 Palafolls Barcelona Spain Spain Active ethyl (2E)-3-(cyclopropylamino)-2-[(2,4-dichloro-3-methylphenyl)carbonyl]prop-2-enoate 953-808-9 - - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active Ethyl (2-acetylamino-5-fluoro-4-isothiocyanatophenoxy)acetate 414-210-9 147379-38-2 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active ethyl (1S,5R,6S)-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate 429-020-1 204254-96-6 - View substance registered dossier
Roche Pharma AG (1) Emil-Barell-Strasse 1 79639 Grenzach-Wyhlen Germany Germany Cease Manufacture ethyl (1S,5R,6S)-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate 429-020-1 204254-96-6 2019 View substance registered dossier
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany Germany Active ethyl (1S,5R,6S)-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate 429-020-1 204254-96-6 2010; 2019 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. - - Active ethyl (1S,5R,6S)-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate 429-020-1 204254-96-6 - View substance registered dossier

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