Registration Dossier
Registration Dossier
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EC number: 701-341-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
DPDP has a low order of acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 840 mg/kg bw
- Quality of whole database:
- There are severalreliable studies of acute toxicity for DPDP. While all show some signs of acute toxicity, these effects occurred only at massively high doses (well above those used in current guidelines). Overall DPDP appears to have a low order of acute toxicity.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 8 400 mg/m³ air
- Quality of whole database:
- There is only one aerosol inhalation study for DPDP, though it appears sufficiently valid to evaluate the endpoint.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
There are acute toxicity data for DPDP for oral, dermal and inhalation routes. The data show a low order of acute toxicity.
Justification for selection of acute toxicity – oral endpoint
While mortality and other effects were observed, they occurred at very high doses that would not be used in current guideline studies. The LD50s were all well above the classification limit of 2000 mg/kg.
Justification for selection of acute toxicity – inhalation endpoint
No effects in a high dose aersol study.
Justification for classification or non-classification
DPDP has a low order of acute toxicity and does not meet the criteria for classification based on its acute toxicity.
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