Registration Dossier
Registration Dossier
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EC number: 850-248-6 | CAS number: 2374784-45-7
Endpoint summary
Administrative data
Description of key information
No data on intermediate 1-(5,7-dihydro-4H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine triflate. The available information is for the free base.
In rats, single oral dose (≥100 mg/kg) caused increased vocalization and urination, and reduced grooming. In addition, impaired coordination, splayed limbs, vocalization, salivation, bristling of hairs, decreased activity, tremors, and death were reported at 600 mg/kg.
In mice, 100 mg/kg was the maximum tolerated dose and a single dose of ≥150 mg/kg was lethal.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Quality of whole database:
- LD50 oral rat >300 to <600 mg/kg
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
On the basis of the data on the free base, the substance is classified:
Acute toxicity (oral) Category 4, H302 Harmful if swallowed
Specific target organ toxicity (single exposure) Category 3, H335 May cause respiratory irritation
Specific target organ toxicity (single exposure) Category 3, H336 May cause drowsiness or dizziness
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