Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 840-203-9 | CAS number: 2295746-51-7
Guidance on Safe Use
Administrative data
First-aid measures
Description of First Aid Measures:
Inhalation: Remove to fresh air. Seek immediate medical attention/advice.
Eye contact: Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician.
Skin contact: Remove contaminated clothing. Flush area with large amounts of water. Use soap. Seek medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Wash out mouth with water. Do not induce vomiting unless directed by medical personnel. Seek medical attention
Most important symptoms and effects, both acute and delayed:
Most important symptoms and effects: No data available
Indication of any immediate medical attention and special treatment needed:
Note to physicians: None
Fire-fighting measures
Extinguishing Media:
Suitable Extinguishing Media Dry chemical, CO2, alcohol-resistant foam or water spray.
Special Hazards Arising from the Substance or Mixture:
Specific hazards arising from the chemical: Strong dust explosion characteristic. High sensitivity of a dust cloud to ignition, based on minimum ignition energy.
Hazardous combustion products: Formation of toxic gases is possible during heating or fire. May include oxides of carbon and nitrogen
Advice for Fire-Fighters:
Special protective equipment for fire-fighters:
Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. Use personal protection equipment.
Accidental release measures
Personal Precautions, Protective Equipment and Emergency Procedures:
Personal precautions: Personnel involved in clean-up should wear appropriate personal protective equipment (see Section 8). Minimize exposure.
For emergency responders: Use personal protection recommended in Section 8.
Environmental Precautions:
Environmental precautions: Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release.
Methods and Material for Containment and Cleaning Up:
Methods for containment: Prevent further leakage or spillage if safe to do so.
Methods for cleaning up: Contain the source of the spill if it is safe to do so. Collect spilled material by a method that controls dust generation. Avoid use of a filtered vacuum to clean spills of dry solids, due to the potential for electrostatic discharge and the strong dust explosion characteristic and high sensitivity to ignition. Clean spill area thoroughly.
Prevention of secondary hazards: Clean contaminated objects and areas thoroughly observing environmental regulations
Handling and storage
Precautions for Safe Handling:
Advice on safe handling: Ground and bond all bulk transfer equipment. Avoid open handling. Minimize dust generation. All conductive elements of the system that contact the dry substance should be properly bonded and grounded and equipped with proper explosion relief or suppression systems. This material should not be flowed through nonconductive ducts or pipes because of the potential for electrostatic discharge ignition. Restricting the use of high resistivity materials, such as plastics, should be considered. Avoid inhalation and contact with skin, eye, and clothing. When handling, use appropriate personal protective equipment. Wash hands and any exposed skin after removal of PPE. Releases to the environment should be avoided. Review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure or environmental releases. Potential points of process emissions of this material to the atmosphere should be controlled with dust collectors, HEPA filtration systems or other equivalent controls.
General hygiene considerations: Handle in accordance with good industrial hygiene and safety practice.
Conditions for safe storage, including any incompatibilities:
Storage Conditions Store at room temperature in properly labeled containers. Keep away from heat, sparks and flames.
Specific end use(s):
Specific use(s) Pharmaceutical process intermediate.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- UN 1325
Shipping information
- Proper shipping name and description:
- Flammable Solid, organic, n.o.s. (Janus kinase 3) TDG
- Language:
- English
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Marine transport (UN RTDG/IMDG)
- UN number:
- UN 1325
Shipping information
- Proper shipping name and description:
- Flammable Solid, organic, n.o.s. (Janus kinase 3)
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- UN 1325
Shipping information
- Proper shipping name and description:
- Flammable Solid, organic, n.o.s. (Janus kinase 3)
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Exposure controls / personal protection
Control parameters:
The purpose of the Occupational Exposure Band (OEB) classification system is to separate substances into different Hazard categories when the available data are sufficient to do so, but inadequate to establish an Occupational Exposure Limit (OEL). The OEB given is based upon an analysis of all currently available data; as such, this value may be subject to revision when new information becomes available.
PF-07202371-S7 Pfizer Occupational Exposure Band (OEB):
OEB 3 - Contact Hazards Unknown (control exposure to the range of 10ug/m3 to < 100ug/m3)
Derived No Effect Level (DNEL) No information available.
Predicted No Effect Concentration (PNEC)
No information available.
Exposure Controls:
Engineering controls: Use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits or within the OEB range.
Environmental exposure controls: Refer to specific Member State legislation for requirements under Community environmental legislation.
Personal protective equipment: Refer to applicable national standards and regulations in the selection and use of personal protective equipment (PPE). Contact your safety and health professional or safety equipment supplier for assistance in selecting the correct protective clothing/equipment based on an assessment of the workplace conditions, other chemicals used or present in the workplace and specific operational processes.
Eye/face protection: Wear safety glasses as minimum protection. (Safety glasses must meet the standards in accordance with EN166, ANSI Z87.1 or international equivalent.).
Hand protection: Wear impervious gloves (e.g. Nitrile, etc.) if skin contact is possible. (Protective gloves must meet the standards in accordance with EN374, ASTM F1001 or international equivalent.).
Skin and body protection: Use protective clothing (uniforms, lab coats, disposable coveralls, etc.) in both production and laboratory areas. (Protective clothing must meet the standards in accordance with EN13982, ANSI 103 or international equivalent.).
Respiratory protection: Whenever excessive air contamination (dust, mist, vapor) is generated, respiratory protection, with appropriate protection factors, should be used to minimize exposure. (e.g. particulate respirator with a half mask, P3 filter). (Respirators must meet the standards in accordance with EN140, EN143, ASTM F2704-10 or international equivalent.). General hygiene considerations: Handle in accordance with good industrial hygiene and safety practice.
Stability and reactivity
Reactivity: No data available
Chemical Stability: Stable under normal conditions.
Explosion data:
Sensitivity to Mechanical Impact: No data available.
Sensitivity to Static Discharge: No data available.
Possibility of Hazardous Reactions: No information available.
Conditions to Avoid: Fine particles (such as dust and mists) may fuel fires/explosions.
Incompatible Materials: As a precautionary measure, keep away from strong oxidizers
Hazardous Decomposition Products: Hazardous decomposition products No data available.
Disposal considerations
Waste Treatment Methods:
Dispose of waste in accordance with all applicable laws and regulations. Member State specific and Community specific provisions must be considered. Considering the relevant known environmental and human health hazards of the material, review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure and environmental release. It is recommended that waste minimization be practiced. The best available technology should be utilized to prevent environmental releases. This may include destructive techniques for waste and wastewater.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
