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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Zirconium salts have been shown to be of low acute oral toxicity with indicative LD50 > 2000 mg/kg

Further animal testing on a corrosive substance is not justified

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute oral toxicity tests were carried out on 4 groups of six male Wistar rats. Test material was administered as a suspension in corm oil by stomach tube. The LD50 doses were calculated from the tables published by Weil.
GLP compliance:
no
Remarks:
Study pre-dates the introduction of GLP
Test type:
standard acute method
Limit test:
no
Specific details on test material used for the study:
Zirconium lactate
Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 g
Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
Oral doses of 0.75, 1.5, 3.0 and 6.0 g/kg of body weight were given as range-finding doses.
Groups of six rats were then given graduated doses of 1.25, 2.5, 5.0 and 10.0 g/kg of zirconium lactate.
No. of animals per sex per dose:
6 male rats per dose.
Control animals:
not specified
Statistics:
The LD50 doses were calculated from the tables published by Weil
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
In a study in male Wistar rats, the oral LD50 was found to be > 10 000 mg/kg bw, the maximum dose tested.
Executive summary:

Groups of male Wistar rats were administered zirconium lactate suspended in corn oil at doses of 1.25, 2.5, 5.0 and 10.0 g/kg. The oral LD50 was found to be greater than the maximum dose tested, i.e. > 10 g/kg bw.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Data from handbook with no method data provided.
GLP compliance:
not specified
Test type:
standard acute method
Species:
rat
Route of administration:
oral: unspecified
Dose descriptor:
LD50
Remarks:
rats
Effect level:
1 688 mg/kg bw
Based on:
test mat.
Remarks:
zirconium tetrachloride
Dose descriptor:
LD50
Remarks:
mice
Effect level:
655 mg/kg bw
Based on:
test mat.
Remarks:
zirconium tetrachloride
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD50 for zirconium tetrachloride is reported to be 1688 mg/kg bw in rats, and 655 mg/kg bw in mice.
Executive summary:

The LD50 for zirconium tetrachloride is reported to be 1688 mg/kg bw in rats, and 655 mg/kg bw in mice.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Data from handbook with no data on method provided.
GLP compliance:
not specified
Test type:
standard acute method
Species:
rat
Dose descriptor:
LD50
Effect level:
3 500 mg/kg bw
Based on:
test mat.
Remarks:
zirconium oxychloride
Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of zirconium oxychloride in rats is reported to be 3500 mg/kg bw.
Executive summary:

The LD50 of zirconium oxychloride in rats is reported to be 3500 mg/kg bw.

Additional information

Justification for classification or non-classification