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EC number: - | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov. 2017 - Jan. 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- adopted 23. Mar. 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Temp.:
- 20 °C
- Vapour pressure:
- 0.004 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0.004 Pa
- Conclusions:
- Vapour pressure at 20°C: 3.89E-03 Pa
Vapour pressure at 25°C: 4.44E-03 Pa - Executive summary:
The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C) according to OECD 104 resp. EU A.4 under GLP conditions using the effusion method (weight loss). Experiment 1-5 (nominal temperature 30 - 90°C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 29 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid. As result it was received, that the vapour pressure is 0.00389 Pa at 20 °C and 0.00444 Pa at 25 °C.
Reference
| T | T | p | Standard Deviation p | RSD p |
| °C | K | Pa | Pa | % |
| 105.0 | 378.2 | 2.26E-02 | 6.35E-03 | 28.1 |
| 120.0 | 393.2 | 2.86E-02 | 6.98E-03 | 24.4 |
| 135.0 | 408.2 | 3.77E-02 | 5.58E-03 | 14.8 |
| 150.0 | 423.2 | 4.22E-02 | 6.81E-03 | 16.2 |
Description of key information
The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C) according to OECD 104 resp. EU A.4 under GLP conditions using the effusion method (weight loss). Experiment 1-5 (nominal temperature 30 - 90°C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 29 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid. As result it was received, that the vapour pressure is 0.00389 Pa at 20 °C and 0.00444 Pa at 25 °C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.004 Pa
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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