Reaction mass of (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene and cis-1-methoxy-4-(2-methoxypropan-2-yl)-1-methylcyclohexane

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 Aug - 21 Sep 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

method to determine freezing temperature

Specific details on test material used for the study:

RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: N/A
- Specific activity: N/A
- Locations of the label: N/A
- Expiration date of radiochemical substance: N/A

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark under nitrogen
- Stability under test conditions: Assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: N/A
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: N/A
- Preliminary purification step (if any): N/A
- Final dilution of a dissolved solid, stock liquid or gel: N/A
- Final preparation of a solid: N/A

FORM AS APPLIED IN THE TEST (if different from that of starting material): N/A

OTHER SPECIFICS: N/A

Key result

Melting / freezing pt.:

< -20 °C

Cooling data for Determinations 1 and 2 are shown in the Table 1 and Table 2.

Table 1: Determination 1

Time (s)	Temperature (°C)	Time (s)	Temperature (°C)	Time (s)	Temperature (°C)
0	22.5	480	-4.0	930	-16.5
30	20.5	510	-5.0	960	-17.0
60	19.0	540	-6.0	990	-17.5
90	16.5	570	-7.0	1020	-17.5
120	14.5	600	-8.0	1050	-18.0
150	12.5	630	-9.0	1080	-18.5
180	10.5	660	-10.0	1110	-19.0
210	9.0	690	-11.0	1140	-19.5
240	8.0	720	-12.0	1170	-20.0
270	6.5	750	-12.5	1200	-20.0
300	4.5	780	-13.0	1230	-20.0
330	3.0	810	-14.0	1260	-20.5
360	1.5	840	-14.5	1290	-20.5
390	0.0	870	-15.0	1320	-20.5
420	-1.5	900	-16.0	1350	-21.0
450	-2.5

Observations: The tet item did not freeze during cooling.

Table 2: Determination 2

Time (s)	Temperature (°C)	Time (s)	Temperature (°C)	Time (s)	Temperature (°C)
0	22.0	510	-6.0	1020	-17.0
30	19.5	540	-7.0	1050	-17.5
60	17.0	570	-8.0	1080	-17.5
90	15.0	600	-9.0	1110	-18.0
120	13.0	630	-9.5	1140	-18.5
150	11.0	660	-10.5	1170	-19.0
180	9.0	690	-11.5	1200	-19.5
210	7.0	720	-12.0	1230	-19.5
240	5.5	750	-12.5	1260	-20.0
270	4.0	780	-13.0	1290	-20.0
300	2.5	810	-13.5	1320	-20.5
330	1.0	840	-14.0	1350	-20.5
360	-0.5	870	-14.5	1380	-20.5
390	-1.5	900	-15.0	1410	-21.0
420	-3.0	930	-15.5	1440	-21.0
450	-4.0	960	-16.0
480	-5.0	990	-16.5

Observations: The test item did not freeze during cooling.

Overall result: Freezing point <-20 ± 0.5˚C (<253 ± 0.5 K)

Conclusions:

The melting point/ freezing point of the substance has been determined to be <-20 ± 0.5˚C (<253 ± 0.5 K).

Executive summary:

The melting point/ freezing point was determined using a technique designed to be compatible with Method EU A.1 and OECD 102. The freezing point of the substance was observed to be < 21˚C on two occassions.

The melting point/ freezing point of the substance has been determined to be <-20 ± 0.5˚C (<253 ± 0.5 K).

Description of key information

EU Method A.1, 2017 - The melting point/ freezing point was determined using a technique designed to be compatible with Method EU A.1 and OECD 102. The freezing point of the substance was observed to be < 21˚C on two occassions.

The melting point/ freezing point of the substance has been determined to be <-20 ± 0.5˚C (<253 ± 0.5 K).