Registration Dossier
Registration Dossier
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EC number: 949-084-9 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
It is worth noting that although the treatment level was set at 200 mg/l in drinking water, a dose of 50 mg/l over 90 days in a sub-chronic study results in biochemical changes with higher protein levels. These parameters were not examined in this study, but even over a shorter exposure period, it is likely that some blood chemistry changes will have occured.
These numbers were higher in females that had been exposed, but mated with non-exposed males, than in non-exposed females where males were exposed, suggesting maternal exposure is the predominant concern.
Note that based on nominal animal weights and typical water consumption, the treatment leval was ca 50 mg/kg/day of vanadyl oxysulphate
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 50 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 50 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
