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EC number: 947-851-2 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 March 2018 to 21 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- other: UV
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.02
- Temp.:
- 20 °C
- pH:
- 7.5
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.32
- Temp.:
- 20 °C
- pH:
- 7.5
- Conclusions:
- The log Pow values based on the two peaks of the test material were determined to be 3.02 and 3.32 by the HPLC method.
- Executive summary:
The partition coefficient of the test item was determined using the HPLC method following OECD guideline 117. In conclusion, based on the two identified test item peaks in the HPLC chromatogram, the log Pow values were determined to be 3.02 and 3.32 at 20 °C.
Reference
Table 1- results of Log Pow values of test item
|
Injection |
Retention time (min) |
Log k’ |
Log Pow |
Mean |
Overall mean |
|
Test item Peak 1 |
Solution 1 |
1 |
7.400 |
0.523 |
3.02 |
3.02 |
3.02 |
2 |
7.400 |
0.523 |
3.02 |
||||
Solution 2 |
1 |
7.400 |
0.523 |
3.02 |
3.02 |
||
2 |
7.393 |
0.523 |
3.02 |
||||
Test item Peak 2 |
Solution 1 |
1 |
9.17 |
0.641 |
3.32 |
3.32 |
3.32 |
2 |
9.18 |
0.641 |
3.32 |
||||
Solution 2 |
1 |
9.200 |
0.642 |
3.32 |
3.32 |
||
2 |
9.180 |
0.641 |
3.32 |
||||
Description of key information
The log Pow values based on the two peaks of the test material were determined to be 3.02 and 3.32 by the HPLC method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.32
- at the temperature of:
- 20 °C
Additional information
The partition coefficient of the test item was determined using the HPLC method following OECD guideline 117. In conclusion, based on the two identified test item peaks in the HPLC chromatogram, the log Pow values were determined to be 3.02 and 3.32 at 20 °C.
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