Triglycerides, C16 and C18 (unsaturated)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - HPLC Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Batch No.of test material: 151124012
- Expiration date of the lot/batch: 01 March 2020
- Purity test date: Not reported

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient
- Stability under test conditions: Stable under normal conditions.

Analytical method:

high-performance liquid chromatography

Type:

log Pow

Partition coefficient:

> 6.2

Temp.:

25 °C

Remarks on result:

other: pH value not reported

Details on results:

The test item chromatographs as a series of peaks in the retention time range of 34 to 46 minutes. The longest retained reference item was DDT (log10Pow = 6.2), which eluted at approximately 9 minutes.
It was therefore concluded that although the method was not strictly applicable to the test item, as the retention time was longer than the retention time of that of the longest eluting standard assessed, the log10Pow value for the test item was greater than 6.2.

Conclusions:

The partition coefficient (log10Pow) of the test item, triglycerides, C16 and C18 (unsaturated), was determined be greater than 6.2.

Executive summary:

A study to determine the partition coefficient of triglycerides, C16 and C18 (unsaturated) was conducted according to OECD 117 and EU A.8 guidelines using HPLC method. The substance, triglycerides, C16 and C18 (unsaturated), is surface active as established from consideration of the chemical structure and as shown by direct measurement of the property. Although the experimental determination of the partition coefficient is not applicable to surface active materials an attempt was made to assess the property of this substance by the HPLC method since often the retention time of a material can provide a good indication of the partition coefficient. The test item eluted as a series of peaks with the retention time in a range of 34 to 46 minutes. The longest retained reference item was DDT (log₁₀P_ow= 6.2), which eluted at approximately 9 minutes.

The partition coefficient (log₁₀P_ow) of triglycerides, C16 and C18 (unsaturated) was determined to be greater than 6.2.

The study was conducted according to standard guidelines and is GLP-compliant and therefore is considered as reliable without restrictions.

Description of key information

The partition coefficient (log₁₀ P_ow) of the test item is > 6.2.

Key value for chemical safety assessment

Log Kow (Log Pow):

6.2

at the temperature of:

25 °C

Additional information

A study to determine the partition coefficient of triglycerides, C16 and C18 (unsaturated) was conducted according to OECD 117 and EU A.8 guidelines (Dunning 2019). The test item is a surface active substance. The experimental determination of partition coefficient is not applicable to surface active materials; however an attempt was made to assess the property of this substance by the HPLC method.

The test item eluted as a series of peaks with the retention time in a range of 34 to 46 minutes. The longest retained reference item was DDT (log₁₀P_ow= 6.2), which eluted at approximately 9 minutes.

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.