Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Remarks:
- Classification based on calculation rules for mixtures of the CLP Regulation.
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Classification based on calculation rules for mixtures of the CLP Regulation.
There is no experimental study reference.
Data are compiled on 10 major components which represent about 92% of the UVCB.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- ECOSAR V1.11
- Author:
- US Environnemental Protection Agency (EPA)
- Year:
- 2 012
- Bibliographic source:
- ECOSAR V1.11
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Version / remarks:
- ECOSAR V1.11
- Principles of method if other than guideline:
- QSAR ECOSAR version 1.11
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
- Test material form:
- liquid: volatile
Constituent 1
Test organisms
- Test organisms (species):
- other: green algae
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- obtained by calculation (UVCB)
- Effect conc.:
- 2.62 mg/L
- Nominal / measured:
- estimated
- Details on results:
- The toxicity to algae were estimated using the following additivity formulas, as recommended in the Regulation (EC) No 1272/2008 (CLP) section 4.1.3.5.2:
∑ Ci / L(E)C50m = ∑ (Ci / L(E)C50i)
Where,Ci = concentration of component i (weight percentage);
L(E)C50i = LC50 or EC50 for component i, in mg/L; L(E)C50m = L(E)C50 of the part of the mixture with test data.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on a weight of evidence approach, the toxicity of assessed substance to algae can be estimated using adequate toxicity data of major constituents, greater than 1% in the mixture.
Ten constituents were considered, representing about 92% of the mixture.
These data are summarized in the above table.
The toxicity to algae were estimated using the following additivity formulas, as recommended in the Regulation (EC) No 1272/2008 (CLP) section 4.1.3.5.2:
∑ Ci / L(E)C50m = ∑ (Ci / L(E)C50i)
Where,Ci = concentration of component i (weight percentage);
L(E)C50i = LC50 or EC50 for component i, in mg/L; L(E)C50m = L(E)C50 of the part of the mixture with test data.
Based on data presented above, the EC50 value for UVCB substance is calculated at 2.62 mg/L for algae. - Executive summary:
With a EC 50 algae calculated value of 2.62 mg/l and some constituents (linalol and camphor with log Kow <4), the substance is classified H411 according to the table 4.1.0 of CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
