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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

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Description of key information

Diethanolamine and Bisphenol A are stable at pH 4, 7, 9. At 25 °C the following DT50 values resulted:
pH 7: 1935 h (Mannich Base 1) and 976 h (Mannich Base 2)
pH 9: 238.1 h (Mannich Base 1) and 117.9 h (Mannich Base 2)

Key value for chemical safety assessment

Half-life for hydrolysis:
117.9 h
at the temperature of:
25 °C

Additional information

One experimental study according to OECD 111 is available investigating the abiotic hydrolysis of the test substance (GLP; Neuland, 2015). Diethanolamine is known to be stable in aqueous solutions. Thus, the study was focused on the hydrolysis of the remaining constituents Bisphenol A, Mannich Base 1 and Mannich Base 2.
A preliminary study was performed at pH 4, 7 and 9 at 50 °C for 5 d. As a result, the components Bisphenol A, Mannich Base 1 and Mannich Base 2 are considered to be stable at pH 4 at 50 °C. Thus, it can be assumed that the constituents are also stable at 25 °C.
The main test was performed at 25 °C with Mannich Base 1 and Mannich Base 2 at pH 7 and 9 for 32 d (hydrolysis was < 90 %). DT50 values of 1935 h (Mannich Base 1, pH 7), 238.1 h (Mannich Base 1, pH 9), 976 h (Mannich Base 2, pH 7) and 117.9 h (Mannich Base 2, pH 9) were calculated. The hydrolysis products of Mannich Base 1 and Mannich Base 2 were analysed by HPLC-UV/LC-MS. 2-(Hydroxymethyl)-4-[1-(p-hydroxyphenyl)-1-methylethyl]phenol is the transformation product of Mannich Base 1 at pH 7 and 9. 4-{1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-1-methylethyl}-2-(hydroxymethyl)phenol is the transformation product from Mannich Base 2 at pH 7 and 9. Diethanolamine is the third transformation product from hydrolysis.
In conclusion, hydrolysis is not a significant degradation process in the environment.