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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
8 May to 12 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
not specified
Type of method:
other: High Performance Liquid Chromatography (HPLC)

Test material

Constituent 1
Chemical structure
Reference substance name:
(1R,2R)-1-amino-2-difluoromethyl)-N- (1-methylcyclopropylsulfonyl)cyclo propanecarboxyamide hydrochloride
EC Number:
943-460-6
Cas Number:
1360828-80-3
Molecular formula:
C9H15CIF2N203S
IUPAC Name:
(1R,2R)-1-amino-2-difluoromethyl)-N- (1-methylcyclopropylsulfonyl)cyclo propanecarboxyamide hydrochloride
Test material form:
solid: particulate/powder
Details on test material:
White solid

Results and discussion

Water solubility
Key result
Water solubility:
8 984.9 mg/L
Temp.:
20 °C
Remarks on result:
other: pH not reported
Details on results:
The mean result of water solubility of Difluorosulfonamide HCl was 8984.9 mg/L at 20°C, the RSD% was 0.45% (n=3).

Any other information on results incl. tables

  Table 1. The Water Solubility Results of Difluorosulfonamide HCl
Test conditions  Test replicates Weight (g)  Sample peak area   Standard peak area  Mean factor  Dilution factor  pH  Water solubility (mg/L)
 Group1  1  4.02  3228577  3178599  0.000139383  20  1.0  9012.0
 Group 1  1  4.02  3237113  3300144  0.000139383  20  1.0  9012.0
Group 2   2  4.01  3231813  3300144  0.000139064  20  1.0  9004.0
 Group 2  2  4.01  3242885  3193105  0.000139064  20  1.0  9004.0
Group 3   3  4.01  3194754  3193105  0.000139948  20  1.0

 8938.6

 Group 3  3  4.01  3192323  3258587  0.000139948  20  1.0  8938.6

Mean water solubility = 8984.9 mg/L, RSD%(n=3)=0.45%

Applicant's summary and conclusion

Conclusions:
The mean result of water solubility of Difluorosulfonamide HCl was 8984.9 mg/L at 20°C, the RSD% was 0.45% (n=3).
Executive summary:

The determinatoin was carried out using the Principles of OECD Guidelines for Testing of Chemicals No. 105 'Water Solubility'.

The mean result of water solubility of Difluorosulfonamide HCl was 8984.9 mg/L at 20°C, the RSD% was 0.45% (n=3).