Registration Dossier
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EC number: 942-066-1 | CAS number: -
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (14d) > 1000 mg/kg (nominal) for Eisenia foetida (OECD 207)
Key value for chemical safety assessment
Additional information
Since no study assessing the toxicity of Reaction mass of bis(2-propylheptyl) hexanedioate and O6-[2,2-bis[[6-oxo-6-(2-propylheptoxy)hexanoyl]oxymethyl]butyl] O1-(2-propylheptyl) hexanedioate to soil macroorganisms is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the source substance Bis(2-propylheptyl) adipate (940-510-9, DPHA) was conducted. The read across is justified since DPHA is the main constituent (80%) of the target substance. The high molecular weight (> 900 g/mole) and log Pow (> 10) of the TMP ester constituent indicate a much lower toxicity of this constituent compared to DPHA. Thus, the study result for the source substance is considered to adequately cover the terrestrial toxicity of the whole multi-constituent substance.
The toxicity of Bis(2-propylheptyl) adipate to earthworms was performed according to GLP and OECD guideline 207 using Eisenia foetida as test organism (Xiaoqian 2015). A test substance concentration of 1000 mg/kg was tested in a limit test. No mortality in the treatment as well as no significant difference in body weight between treatment and control were observed during an exposure time of 14 days. Thus, the 14d-LC50 value is determined to be > 1000 mg/kg. Based on this result Reaction mass of bis(2-propylheptyl) hexanedioate and O6-[2,2-bis[[6-oxo-6-(2-propylheptoxy)hexanoyl]oxymethyl]butyl] O1-(2-propylheptyl) hexanedioate is considered to be not harmful to soil macroorganisms.
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