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EC number: 941-174-6 | CAS number: -
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar toxicological and ecotoxicological properties because they share structural similarities with common functional groups: quaternary amines, esters, and fatty acid chains varying in their length and degree of (un)saturation. Moreover, the fatty acid chains are chemically simple structures which have no structural alerts for toxicity, and which are closely related to substances of known low toxicity (i.e. stearic acid, oleic acid, linoleic acid, linolenic acid). Furthermore, the substances can be expected to have comparable breakdown products (MDEA or MDIPA and long chain fatty acids).
This read-across hypothesis corresponds to scenario 2 - different compounds have qualitatively and quantitatively the same type of effects - of the read-across assessment framework i.e. properties of the target substance MDIPA-Esterquat C16-18 and C18 unsatd. are predicted to be similar to those of the source substances MDEA-Esterquat C16-18 and C18 unsatd. and MDIPA Esterquat C18 unsatd.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See justification for read-across attached to chapter 13 of this IUCLID file.
3. ANALOGUE APPROACH JUSTIFICATION
See justification for read-across attached to chapter 13 of this IUCLID file.
4. DATA MATRIX
See justification for read-across attached to chapter 13 of this IUCLID file. - Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Species:
- Avena sativa
- Duration:
- 17 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 47.4 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: seedling emergence , growth, phytotoxicity
- Species:
- Avena sativa
- Duration:
- 17 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 47.4 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
- Species:
- Lactuca sativa
- Duration:
- 17 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 47.4 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: seedling emergence , growth, phytotoxicity
- Species:
- Lactuca sativa
- Duration:
- 17 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 47.4 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- phytotoxicity
Reference
Description of key information
Avena sativa (oats) and dicot Lactuca sativa (lettuce)
17 d NOEC based on seed germination: >47.4 mg a.i./kg dry soil
17 d NOEC values based on plant growth (length and dry weight): >47.4 mg a.i./kg dry soil
OECD guideline 208, RL1, GLP; read-across from MDEA-Esterquat C16-18 and C18 unsatd.
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for terrestrial plants:
- 47.4 mg/kg soil dw
Additional information
No experimental data are available for the target substance MDIPA Esterquat C16-18 and C18 unsatd. However, a toxicity study in terrestrial plants is available for the source substance MDEA-Esterquat. A justification for read-across isattached to Iuclid section 13.
The effect of MDEA-Esterquat C16-18 and C18 unsatd. on seedling emergence and growth of the monocotyl oat (Avena sativa) and dicotyl lettuce (Lactuca sativa) crops was studied at nominal concentrations of 0 and 47.4 mg a.i./kg dry soil (1000 mg dispersion/kg dry soil). The study was conducted according to OECD TG 208. The growth medium used in the test was a mixture of natural soil and sand (1:1; pH 7.5; organic matter 1.1%). On day 17, the surviving plants per pot were recorded and cut at soil level for measuring the plant height and dry weight in the seedling emergence and vegetative vigour test, respectively. Seed germination was not affected by the MDEA-Esterquat C16-18 and C18 unsatd. The 17 d NOEC based on seed germination was >47.4 mg a.i./kg dry soil. In the vegetative vigour test, the plant dry weight and plant height were not affected by MDEA-Esterquat C16-18 and C18 unsatd. treatment. The 17 d NOEC values based on plant growth (length and dry weight) was >47.4 mg a.i./kg dry soil.
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