1-Propanesulfonamide, N-[3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-

Guidance on Safe Use

First-aid measures

Description of first aid measures

General advice: Do not leave the victim unattended.

If inhaled:

Move to fresh air.

If unconscious, place in recovery position and seek medicaladvice.

If symptoms persist, call a physician.

In case of skin contact:

If on skin, rinse well with water.

In case of eye contact:

Flush eyes with water as a precaution.

Remove contact lenses.

Protect unharmed eye.

Keep eye wide open while rinsing.

If eye irritation persists, consult a specialist.

If swallowed:

Keep respiratory tract clear.

Do not give milk or alcoholic beverages.

Never give anything by mouth to an unconscious person.

If symptoms persist, call a physician.

Most important symptoms and effects, both acute and delayed

None known.

Indication of any immediate medical attention and special treatment needed

Treatment: The first aid procedure should be established in consultation with the doctor responsible for industrial medicine.

Fire-fighting measures

Extinguishing media

Suitable extinguishing media:

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing media:

High volume water jet

Special hazards arising from the substance or mixture

Specific hazards during firefighting:

Do not allow run-off from fire fighting to enter drains or water courses.

Hazardous combustion products:

In case of fire hazardous decomposition products may be produced such as:

Carbon monoxide

Nitrogen oxides (NOx)

Hydrogen fluoride

hydrogen bromide

Advice for firefighters

Special protective equipment for firefighters:

Wear self-contained breathing apparatus for firefighting if necessary.

Further information:

Collect contaminated fire extinguishing water separately. This must not be discharged into drains.

Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.

Accidental release measures

-Personal precautions

Avoid dust formation.

Avoid breathing dust.

-Environmental precautions:

Prevent product from entering drains.

Prevent further leakage or spillage if safe to do so.

-Methods and material for containment and cleaning up

Methods for cleaning up: Keep in suitable, closed containers for disposal.

Handling and storage

Precautions for safe handling

Advice on safe handling:

Smoking, eating and drinking should be prohibited in the application area.

Dispose of rinse water in accordance with local and national regulations.

Advice on protection against fire and explosion:

Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures: When using do not eat or drink. When using do not smoke.

Wash hands before breaks and at the end of workday.

-Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Electrical installations / working materials must comply with the technological safety standards.

Storage class (TRGS 510): 13, Non Combustible Solids

Storage temperature: Store at room temperature.

Protected from heat and light

Protect from moisture.

Further information on storage stability: Keep in a dry place. No decomposition if stored and applied as directed.

Packaging material: Suitable material: Stainless steel, Polyethylene bag in metal drum

-Specific end use(s): Intermediate in the synthesis of an active pharmaceutical compound

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,N.O.S.

Chemical name:

(N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide)

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

Labels:

9

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

3077

Shipping

Labels:

9

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

Chemical name:

N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-
difluorophenyl]-1-propanesulfonamide

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

EmS code:

F-A

S-F

Labels:

9

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

3077

Shipping information

Proper shipping name and description:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

Chemical name:

N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-
difluorophenyl]-1-propanesulfonamide

Class or division:

Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances

Packing group:

Packing group III: Substances presenting low danger

Remarks:

Packing instruction (cargo aircraft) (passenger aircraft) : 956 Packing instruction (LQ) : Y956

Labels:

9

Remarks

SpecialProvisions

Exposure controls / personal protection

Personal protective equipment

-Eye protection :

Eye wash bottle with pure water

Tightly fitting safety goggles

-Hand protection Material : Protective gloves

Remarks: The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. This recommendation is only valid for the product mentioned in the safety data sheet and provided by us and for the application specified by us. Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time. The suitability for a specific workplace should be discussed with the producers of the protective gloves.

-Skin and body protection : Dust impervious protective suit Choose body protection according to the amount and concentration of the dangerous substance at the work place.

Stability and reactivity

1. Reactivity

No dangerous reaction known under conditions of normal use.

2. Chemical stability

Stable under normal conditions.

Decomposes at elevated temperatures.

Exothermic reaction

3. Possibility of hazardous reactions

Hazardous reactions : No data available

No decomposition if stored and applied as directed.

Dust may form explosive mixture in air.

4. Conditions to avoid

No data available

5. Incompatible materials

Materials to avoid: No data available

6. Hazardous decomposition products

No data available

Disposal considerations

Waste treatment methods

Product:

The product should not be allowed to enter drains, water courses or the soil.

Do not contaminate ponds, waterways or ditches with chemical or used container.

Send to a licensed waste management company.

Contaminated packaging:

Empty remaining contents.

Dispose of as unused product.

Empty containers should be taken to an approved waste

handling site for recycling or disposal.

Do not re-use empty containers.