Registration Dossier
Registration Dossier
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EC number: 939-992-3 | CAS number: 1195028-55-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The gene mutation tests are negative for the Na salt (CAS 1325 -54 -8, source chemicals): All available in vitro tests in genetic toxicity are GLP compliant and scored Klimisch 1 and 2 and all gave negative results.
The information recovered from lithium, leads to the conclusion that lithium is considered to have no genotoxic potential.
In the read-across study it is justified that the endpoint Genetic toxicity for target chemical CAS 1195028 -55 -7 can be assessed from the Na salt.
There is no need to carry out in vivo studies in genetic toxicity.
Justification for selection of genetic toxicity endpoint
Read-across from source chemical CAS 1325-54-89 is considered relevant and reliable.
Short description of key information:
The "in vitro" genetic toxicity testing has been performed with source chemical CAS 1325-54-8. Information related to genotoxic properties of lithium has been included in the read-across approach study.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Following the criteria as described in Directive 67/548/EEC and Annex 1of Regulation (EC) No. 1272/2008, and based on the available data, the substance is not classified for genetic toxicity
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