1,4-Benzenedisulfonic acid, 2,2'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)imino[6-[bis(2-hydroxypropyl)amino]-1,3,5-triazine-4,2-diyl]imino]]bis-, sodium salt (1:6)

Endpoint summary

Description of key information

Although experimental data on toxicokinetics are not available. Due to an  analogue approch,  it can be stated that after oral exposure, rats excrete the substance with high probability almost completely in the faeces. 

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Additional information

Published results are available of a study done with CAS 13863 -31 -5 (Muecke et. al, 1975) similar to OECD Guideline 417 following the fate of¹⁴C-labeled test substance in the rat. The test substance is another analogue substance of the category of derivatives of 4,4’-bis(1,3,5-triazinyl-2-yl)amino)stilbene-2,2’-disulfonic acid, each with one anilino and one alkyl amino moiety. After an oral dose of approximately 5 mg/kg bw nearly all the administered radioactivity was rapidly excreted with the faeces. The average residue in all tissues examined was less than 0.005 ppm test substance equivalents. Most of the radioactivity in the faeces was not extractable with either methanol or water because probably the compound is tightly bound to cellulose in the faeces. The tested substance (CAS 13863-31-5) is the salt of an di-sulfonated derivative, whereas the substance defined in section 1 is a salt of a hexa-sulfonated derivative. This implies, that that the substance defined in section 1 is even less lipophilic. Therefore it can be stated that after oral exposure, rats excrete the substance with high probability almost completely in the faeces within 48 hours.