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EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 March 2011 to 25 March 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU & OECD test guidance in compliance with GLP and reported with a valid GLP certificate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- Name: Reactive Orange F08-0314
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -4.5
- Temp.:
- 20 °C
- pH:
- > 4.59 - < 4.66
- Details on results:
- Reactive Orange F08-0314 was not detected in the n-octanol phase.
Any other information on results incl. tables
Measured concentrations
Ratio of solvents (n-Octanol : Water) |
Measured concentration of Reactive Orange F08-0314 in n-octanol phase(μg/ml) |
Measured concentration of Reactive Orange F08-0314 in water phase(μg/ml) |
pH |
1:1 |
<0.13* <0.13 |
5212 5404 |
4.66 |
<0.13 <0.13 |
5432 5614 |
4.64 |
|
<0.13 <0.13 |
5570 5516 |
4.64 |
|
Mean (C) |
<0.13 |
5458 |
4.65 |
RSD% |
- |
3 |
- |
Meas. Test item (M) |
<3.2μg |
136mg |
- |
Total quantity of test item (Mo+Mw) in the two-phase system: |
136 mg |
||
Recovery: |
102% |
||
2:1 |
<0.13* <0.13 |
7687 7337 |
4.60 |
<0.13 <0.13 |
7952 8104 |
4.60 |
|
<0.13 <0.13 |
8062 8124 |
4.59 |
|
Mean (C) |
<0.13 |
7878 |
4.60 |
RSD% |
- |
4 |
- |
Meas. Test item (M) |
<4.3μg |
130mg |
- |
Total quantity of test item (Mo+Mw) in the two-phase system: |
130mg |
||
Recovery: |
97% |
||
1:2 |
<0.13* <0.13 |
4217 4138 |
4.62 |
<0.13 <0.13 |
4022 4492 |
4.63 |
|
<0.13 <0.13 |
4091 4424 |
4.63 |
|
Mean (C) |
<0.13 |
4233 |
4.63 |
RSD% |
- |
4 |
- |
Meas. Test item (M) |
<2.1μg |
142mg |
- |
Total quantity of test item (Mo+Mw) in the two-phase system: |
142mg |
||
Recovery: |
106% |
||
* Corresponds to the LOQ after the extraction
Calculated partition coefficient (Pow) and Log Pow
Ratio of solvents (n-Octanol : Water) |
Partition coefficient |
Log Partition coefficient |
Pow |
Log Pow |
|
1:1 |
<0.000024 |
<-4.6 |
2:1 |
<0.000016 |
<-4.8 |
1:2 |
<0.000030 |
<-4.5 |
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the partition coefficient (Pow) of Reactive Orange F08-0314 in an n octanol - water two-phase system was determined to be less than 3.0 *.10-5 using shake flask method.
The log Pow is less than -4.5. The substance is not considered to have the propensity to bioaccumulate. - Executive summary:
This study has been performed in accordance with the study plan, Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 107, "Partition Coefficient (n-octanol/water): Shake Flask Method", adopted July 27, 1995 and Council Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Annex, Part A, Methods for the determination of physico-chemical properties, A.8 "Partition Coefficient", EEC Publication No. L142. and the Principles of Good Laboratory Practice (GLP). The study is reported with a valid GLP certificate.
The objective of the study was to determine the partition coefficient of the test item. The partition coefficient is the ratio of equilibrium concentrations of a dissolved test item in a two-phase system consisting of two largely immiscible solvents.
Summary of the results:
Partition coefficient (Pow) of Reactive Orange F08-0314 was determined using the shake-flask method.
Pow < 3.0 * 10-5
log Pow < -4.5
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