Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 627-725-0 | CAS number: 398489-26-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Tert-butyl 3-oxoazetidine-1-carboxylate
- EC Number:
- 627-725-0
- Cas Number:
- 398489-26-4
- Molecular formula:
- C8H13NO3
- IUPAC Name:
- Tert-butyl 3-oxoazetidine-1-carboxylate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Batch Nr : RC10050008
Purity : 99,4 % (w/w)
Test substance storage : at room temperature, protected from light
Stability : stable under storage conditions
Expiry date : 22 June 2013
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- ca. 18 000 mg/L
- Temp.:
- 19.6 °C
- pH:
- ca. 6
- Water solubility:
- ca. 17 100 mg/L
- Temp.:
- 19.6 °C
- pH:
- 5.7
- Water solubility:
- ca. 17 100 mg/L
- Temp.:
- 19.6 °C
- pH:
- 6
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of PAM-Azetidinone, calculated as the mean value of the 3 determinations, is 17 400 mg/l. - Executive summary:
The initially added amount of test substance was 50 g per litre deionised water. The measured concentrations after filtration by 0.45 μm cellulose acetate membrane sterile syringe filters were as follows:
18’000 mg/l after 96 h (i.e. 72 h at 31.0 ± 0.5°C and 24 h at 19.6 ± 0.6°C), pH 6.0
17’100 mg/l after 120 h (i.e. 96 h at 31.0 ± 0.5°C and 24 h at 19.6 ± 0.6°C), pH 5.7
17’100 mg/l after 144 h (i.e. 120 h at 31.0 ± 0.5°C and 24 h at 19.6 ± 0.6°C), pH 6.0
The water solubility of PAM-Azetidinone, calculated as the mean value of the three determinations, is 17’400 mg/l.
The test is valid, since the concentrations of at least the last 2 vessels do not differ by more than 15%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
