Reaction mass of sodium chloride and sodium iodide and sodium sulphate

Toxicity to soil microorganisms

Administrative data

Endpoint:

toxicity to soil microorganisms

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Chemical Substance Search (Sodium iodide)

Author:

Registered substances-ECHA

Bibliographic source:

http://echa.europa.eu/web/guest/information-on-chemicals/registered-substances?p_p_id=48_INSTANCE_Rfk8&_48_INSTANCE_Rfk8_iframe_q=Hydroquinone&_48_INSTANCE_Rfk8_iframe_legal=true

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Deviations:

not specified

Principles of method if other than guideline:

Over 170 chemical agents were screened for antiprotozoal action in bovine ruminal fluid. Compounds were tested at 0.1 and 0.05% concentrations. Tested compounds included inorganic compounds, antibiotics, biocides, neuromuscular agents, arsenicals, plant and animal hormones, antimalarials, surface-active agents, anthelmintics, and many others.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Sodium iodide

EC Number:

231-679-3

EC Name:

Sodium iodide

Cas Number:

7681-82-5

Molecular formula:

INa

IUPAC Name:

Sodium iodide

Details on test material:

As sodium iodide is with 56% the main compound of this reaction mass a read-across of data from this salt to cover this endpoint for the reaction mass is assumed to be acceptable.

Test organisms

Test organisms (inoculum):

soil

Study design

Total exposure duration:

24 h

Results and discussion

Effect concentrations

Duration:

24 h

Dose descriptor:

other: not reported

Effect conc.:

0.1 other: %

Applicant's summary and conclusion

Executive summary:

Over 170 chemical agents were screened for antiprotozoal action in bovine ruminal fluid. Compounds were tested at 0.1 and 0.05% concentrations. Tested compounds included inorganic compounds, antibiotics, biocides, neuromuscular agents, arsenicals, plant and animal hormones, antimalarials, surface-active agents, anthelmintics, and many others. The most active compounds were cupric sulfate, nickel sulfate, nitrofurazone, hydrogen peroxide, dodecyl sodium sulfate, pelargonic acid, iodoacetic acid, 1-diethylaminoethylamino-4-methylthiaxanthrone, sodium arsanilate, sodium arsenate, bismuth glycolyl arsanilate, 1-β-hydroxyethyl-2-methyl-5-nitroimidazole, and p-nitroaniline. Copper ion was not particularly effective against entodinia; nickel ion had no effect on holotrichs. Hydrogen peroxide and iodoacetic acid were effective at a concentration of 0.005%. Anionic surface-active agents were very effective, especially long-chain sulfates and phosphates. These antiprotozoal agents warrant further in vivo studies for possible use in treating or curing bloat in ruminants.