Registration Dossier
Registration Dossier
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EC number: 907-349-6 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Male and female ICR mice were exposed to 0.5, 2.5 or 5 ml/kg of octadecyl isocyanate which was administered as a single i.p. injection. Bone marrow cells, collected 24, 48 and 72 hours after treatment, were examined microscopically for micronucleated polychromatic erythrocytes (equivalent to OECD TG 474; Putman 1989). No change in the ratio of polychromatic erythrocytes to total erythrocytes was observed in male or female mice in the test article treated groups,suggesting that the test article did not induce bone marrow toxicity. No significant increases in micronucleated polychromatic erythrocytes were observed at 24, 48 or 72 hours after dose administration in males or females. The results of the assay indicate that under the conditions described, octadecyl isocyanate did not induce a significant increase in micronucleated polychromatic erythrocytes in male or female ICR mice. Therefore, octadecyl isocyanate was concluded to be negative in the mouse micronucleus assay.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Not classified under Annex I of Directive 67/548/EEC. According to Annex I of Regulation (EC) No 1272/2008 no classification is required for genetic toxicity.
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