Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-436-4 | CAS number: 61932-63-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Worker DNELs have not been derived for pigments of the Naphtol AS group because the substances of this category did not cause relevant toxictiy in any test performed according to the information requirements.
- the substances of this category did not cause lethal effects in rats after administration of a single oral dose of >= 2000 mg/kg, a single dermal dose of 2000 mg/kg or a single inhalation concentration of 1580 mg/cubic metre,
- the substances of this category are not irritating and do not have to be classified as eye or skin irritants,
- the substances of this category caused no relevant systemic toxic effects in several subacute studies in rats (NOAEL 1000 mg/kg/day),
- the substances of this category caused no systemic toxic effects, no effects on fertility or development in a Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test (OECD TG 422; NOAEL 1000 mg/kg bw/day) and a
Reproduction / Developmental Toxicity Screening Test (OECD TG 421; NOAEL 1000 mg/kg bw/day),
- the absence of effects in the above-mentioned toxicity endpoint tests indicates that the substances of this category do not interact with living cells/tissues, and
- it is unlikely that the substances of this category become systemically bioavailable due to their extremely low solubility in water and low solubility in n-octanol. The substances of this category are not likely to be systemically available after oral, dermal or inhalation exposure.
Therefore no DNELs for systemic effects have been derived.
Naphtol AS Pigments do not cause irritation, corrosion or sensitization. They are considered unlikely to become bioavailable in the skin and are considered not to be classified regarding respiratory tract irritation. No substance specific effects are expected for the pigments of this category after local exposure, therefore no DNELs for local effects have been derived. Apart from that, relevant occupational exposure limits for inert dusts should be applied.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
DNELs for the general population have not been derived for pigments of the Naphtol AS group because the substances of this category did not cause relevant toxicity in any test performed according to the information requirements.
- the substance / supporting/surrogate substances did not cause lethal effects in rats after administration of a single oral dose of >= 2000 mg/kg and >5000 mg/kg, or a single dermal dose of 2000 mg/kg or >5000 mg/kg
- the substance / supporting/ surrogate substances are not irritating and do not have to be classified as eye or skin irritants,
- the substance / supporting/surrogate substances caused no relevant systemic toxic effects in several subacute studies in rats (NOAEL 1000 mg/kg/day),
- the substance / supporting/surrogate substances caused no effects on development in a Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test (NOAEL 1000 mg/kg bw/day)
- the absence of effects in the above-mentioned toxicity endpoint tests indicates that the substances of this category do not interact with living cells/tissues, and
- it is unlikely that the substances of this category become systemically bioavailable due to their extremely low solubility in water and low solubility in n-octanol. The substances of this category are not likely to be systemically available after oral, dermal or inhalation exposure.
Therefore no DNELs for systemic effects have been derived.
Naphtol AS pigments do not cause irritation, corrosion or sensitization. They are considered unlikely to become bioavailable in the skin and are considered not to be classified regarding respiratory tract irritation. No substance specific effects are expected for the pigments of this category after local exposure, therefore no DNELs for local effects have been derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
