Registration Dossier
Registration Dossier
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EC number: 906-484-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Reaction mass of DIPE and 2-methylpent-2-ene was found to be not eye irritating in vivo (according to guideline OECD 405) and in vitro (according to guideline OECD 437) and not skin irritanting (according to guideline EU B.46).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
One in vitro skin irritation study (according to guideline EU B.46) conducted under GLP showed that reaction mass of DIPE and 2-methylpent-2-ene is not skin irritating.
One in vivo eye irritation study conducted under GLP and according to OECD 405 (key study) showed no eye irritation. A previously conducted in vitro study according to the stepwise testing approach (according to OECD 437, BCOP test) showed also no eye irritation.
No risk assessment has to be conducted for these endpoints since the substance is not classified.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
One skin irritation study conducted under GLP showed that reaction mass of DIPE and 2-methylpent-2-ene is not skin irritating.
One in vivo eye irritation study conducted under GLP and according to OECD 405 (key study) showed no eye irritation. A previously conducted in vitro study according to the stepwise testing approach (according to OECD 437, BCOP test) showed also no eye irritation.
Consequently, reaction mass of DIPE and 2-methylpent-2-ene
has to be classified as not eye irritating and not skin irritating according to the criteria of Regulation (EC) No 1272/2008.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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