Registration Dossier
Registration Dossier
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EC number: 906-484-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 22 900 mg/m³ air
Additional information
Acute toxicity: oral - waived as inhalation data are avaiable.
Acute toxicity: dermal - waived as inhalation is the more important exposure pathway.
Acute toxicity: Inhalation
A single four hours nose-only exposure of reaction mass of DIPE and 2-methylpent-2-ene to CRL: (WI) BR rat followed by a 14-day observation period at a dose level 22.9 mg/L was not associated with any test item-related macroscopic findings.
Justification for classification or non-classification
The criteria for classification as acute toxic (inhalative) of reaction mass of DIPE and 2-methylpent-2-ene according to the Directive 67/548/EEC and Regulation (EC) 1272/2008 are not met.
Narcotic effects of reaction mass of DIPE and 2 -methylpent-2-ene
were not observed during testing of acute inhalation toxicity (nose-only) with the test item according to the OECD 403 guideline under GLP.However, as a precautionary measure, the reaction mass is classified as R67 and Category 3 (H336) for narcotic effects according to Directive 1999/45/CE and Regulation (EC) 1272/2008 repectively due to the official classification with H336 of DIPE, a main constituent present at ca. 40%.
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