(chloromethyl)(methoxy)dimethylsilane

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Good laboratory practice guideline study (OECD).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Name of test material (as cited in study report): Silane 434099 VP
- Substance type: intermediate
- Physical state: liquid
- Stability under test conditions: pure: stable, in Water: hydrolysis in water with formulation of methanol
- Storage condition of test material: room temperature in the dark

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
not applicable

Sampling and analysis

Analytical monitoring:

yes

Details on sampling:

- Sample storage conditions before analysis: analyzed directly, rest stored in refrigerator (4°C)

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Daphnia magna (Straus), clone 5
- Source: supplied by Umweltbundesamt, Institut für Wasser-, Boden-, und Lufthygiene, Berlin, Germany in 1997
- Age at study initiation (mean and range, SD): 6-22.5 hours old
- Method of breeding: same water quality as in test (pH, main ions, total hardness)


ACCLIMATION
- Acclimation period: 6 hours
- Acclimation conditions (same as test or not):same as test

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Remarks on exposure duration:

NOT_SPECIFIED

Post exposure observation period:

not applicable

Test conditions

Hardness:

2.5 mmol/l as CaCO3

Test temperature:

21 °C

pH:

7.9 to 8.0

Dissolved oxygen:

at least 8.0 mg/l

Salinity:

freshwater, not applicable

Nominal and measured concentrations:

100 mg/l (nominal) 97 mg/l (mean, measured)

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass beakers of 250 ml filled with 150 ml.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates):2
- No. of vessels per control (replicates):2


TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionized water
- Alkalinity: 0.8 mmol/l
- Ca/mg ratio: 4:1


OTHER TEST CONDITIONS
- Adjustment of pH: buffered solution



EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : IC50 at 24 and 48 h

Reference substance (positive control):

yes

Remarks:

potassium dichromate

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 3

Duration:

24 h

Dose descriptor:

NOEC

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 4

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

none

Results with reference substance (positive control):

not given

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Substance is not toxic or harmful to daphnids.

Executive summary:

The subastance was administered to Daphnia magna in a limit test at a concentration of 100 mg/l (nominal) according to OECD guideline 202. No immobilization occured neither after 24 hours nor after 48 h.