2-Propenal, 3-(5,5-dimethyl-1,3-dioxan-2-yl)-2-methyl-, (2E)-

Toxicity to microorganisms

Administrative data

Endpoint:

toxicity to microorganisms

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-Guideline, non-GLP, limitations in reporting but otherwise adequate for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Oxygen consumption according to ROBRA

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

(2E)-3-(5,5-dimethyl-1,3-dioxan-2-yl)-2-methylprop-2-enal

EC Number:

610-698-4

Cas Number:

51575-61-2

Molecular formula:

C10 H16 O3

IUPAC Name:

(2E)-3-(5,5-dimethyl-1,3-dioxan-2-yl)-2-methylprop-2-enal

Details on test material:

- Name of test material (as cited in study report): MBDA

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

Vehicle: Cremophor RH 40 (100 mg/L). An emulsion was reported to be formed.

Test organisms

Test organisms (species):

other: not specified

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Test temperature:

21.8 and 22.2 °C

pH:

4.81-7.51

Nominal and measured concentrations:

- Nominal concentrations: 0 (control), 156.25, 312.5, 625, 1250, 2500, 5000 and 10000 mg/L

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC10

Effect conc.:

372 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: oxygen consumption

Remarks on result:

other: non-neutralised test solutions

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2 639 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: oxygen consumption

Remarks on result:

other: non-neutralised test solutions

Any other information on results incl. tables

PH	Concentration (mg/L)	Oxygen use (mg/L*min)
		1	2	MW	MW%
7.51	BLW (Cremophor)	2.25	2.1	2.175	100
7.51	BLW (Cremophor)	2.15	2.2
4.81	10000	0.15	0.15	0.15	6.9
6.70	5000	0.65	0.65	0.65	29.9
7.19	2500	1.15	1.1	1.125	51.7
7.41	1250	1.45	1.55	1.5	69.0
7.48	625	1.6	1.65	1.625	74.7
6.95	1000 (neutral)	0.15	0.1	0.125	5.7
7.44	BLW (Cremophor)	2.15	2.05	2.05	100
7.44	BLW (Cremophor)	2.1	1.9
7.50	312.5	2.05	1.85	1.95	95.1
7.51	156.25	2.05	2.1	2.075	101.2