Registration Dossier
Registration Dossier
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EC number: 618-233-7 | CAS number: 890707-28-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8.11.19 - 16.3.2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181 CIPAC Handbook H (1998)
- Version / remarks:
- 1998
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Medium:
- other: p-xylene
- Solubility:
- < 10 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 33 - < 40 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- methanol
- Solubility:
- > 40 - < 50 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- acetone
- Solubility:
- > 160 - < 200 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- ethyl acetate
- Solubility:
- > 67 - < 80 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- dimethylformamide
- Solubility:
- > 250 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- DMSO
- Solubility:
- > 250 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Conclusions:
- 2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.
- Executive summary:
The solubility of 2 -Amino-5 -chloro-N,3 -dimethylbenzamide in several organic solvents is determined according to CIPAC MT 181 by adding successive measured volumes of solvent to a known mass of the test item until complete dissolution is observed. Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide was determind as followed:
- p-xylene lower than 10 g/L.
- dichloromethane between 33 g/L and 40 g/L.
- methanol between 40 g/L and 50 g/L.
- acetone between 160 g/L and 200 g/L.
- ethyl acetate between 67 g/L and 80 g/L
- dimethylformamide higher than 250 g/L.
- dimethylsulfoxide higher than 250 g/L.
as determien to
Reference
Description of key information
Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide in organic solvents was determined according to CIPAC 181 (1998).
2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.
Key value for chemical safety assessment
Additional information
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