Registration Dossier
Registration Dossier
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EC number: 617-081-9 | CAS number: 80473-92-3
Guidance on Safe Use
Administrative data
First-aid measures
Ingestion: Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.
Inhalation: Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed subject should be kept warm and at rest. Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects, which may be delayed.
Skin contact: Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.
Eye contact: Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.
Fire-fighting measures
Fire and explosion hazards: This material is non-combustible. Dust clouds are potentially extremely sensitive to ignition from incendive electrostatic discharges. Dust clouds are of very low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer observed up to 400 °C. Ignition of a dust cloud produces a strong dust explosion. High pressure between 8 and 10 bar is produced during a dust explosion.
Suitable extinguishing media: No special requirements needed. Water is recommended for fires involving packaging.
Special protective equipment and precautions for firefighters: Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from the fire area if possible without increased personal risk. If possible, contain and collect firefighting water for later disposal.
Specific hazards arising from the material: Toxic, corrosive or flammable thermal decomposition products, which might include fluorine and sulphur compounds, are expected when the material is exposed to fire.
Accidental release measures
Personal Precautions: Fence or cordon the affected area and do not allow individuals to touch or walk through the spilled material unless wearing appropriate protective clothing. Avoid dust generation.
Environmental Precautions: Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.
Clean-up Methods: Collect and place it in a suitable, properly labelled container for recovery or disposal. After all solid or absorbent material has been collected, the area should be vacuumed with HEPA filter-equipped apparatus.
Decontamination Procedures: No specific decontamination or detoxification procedures have been identified for this material.
Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of
this SDS), for clean-up and decontamination operations.
Handling and storage
GSK Process Hazard Category: 4
General requirements: Avoid dispersion as a dust cloud. Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to provide routine control of fire and explosion hazards during handling of this material.
Ignition controls: Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules. Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but have been recorded up to 100 mJ. Minimise the use of plastics when handling this material. Handle and store this material only in conductive or anti-static plastic liners (bags) since normal plastics are known to be capable of producing electrostatic discharges of up to 4 mJ, ensuring that any containers into which they are placed are themselves of a conductive material and earthed (grounded). Due to the very low minimum ignition energy for this powder, it is advisable to treat this material
as if it is a flammable solvent vapour. The maximum surface temperature of enclosures potentially exposed to this material should be the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum temperature of 325 °C.
Protective systems: Assess operations based upon available dust explosion information to determine the suitability of preventive or protective systems as precautionary measures against possible dust explosions. If prevention is not possible, consider protection by use of containment, venting or suppression of dust handling equipment. Where explosion venting is considered the most appropriate method of protection, vent areas should preferably be calculated based on the Kst rather than the St value. If nitrogen purging is considered as the protective system, it must operate with an oxygen level below the limiting oxygen concentration. The system should include an oxygen monitoring and shut-down facility in the event of excessive oxygen being detected. At both ambient and low humidity, this material is of low conductivity. Generation of electrostatic charge is considered likely to occur even when handled in an earthed (grounded) environment. At ambient humidity, this material has a very long charge relaxation time. Accumulation of electrostatic charge is considered very likely to occur even when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material might present a very high risk of producing an electrostatic discharge. At low humidity, this material has an extremely long charge relaxation time. Accumulation of electrostatic charge will occur even when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material might present a very high risk of producing an electrostatic discharge.
Conditions for safe storage: Keep in tightly closed containers or packages away from moisture and away from sources of ignition. Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately 20 degrees C).
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Engineering controls
Exposure controls: This material has been assigned to GlaxoSmithKline Occupational Hazard Category 3 with a hygiene guide of 10-<100 mcg/m3. An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.
Containment: Open handling is not recommended. Consider segregating operations, use of enclosures and sealed transfer systems.
Ventilation: Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a means of removing material incidentally released.
Administrative: Entry to the working area should be controlled. Doors with interlocks may be needed for materials airlocks and locker rooms. Only equipment and supplies necessary for job activities should be taken into working area.
Personal protective Equipment
Eye protection: Wear approved safety glasses with side shields or cover goggles if eye contact is possible.
Gloves: The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient data are available and further guidance should be sought from your local EHS department.
Respirators: If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations present, required protection factor as well as hazards, physical properties and warning properties of substances present. Follow local regulations for respirator use in the workplace.
Other equipment or procedures
An eye wash station should be available. Consider control procedures for maintenance, cleaning and emergencies. Wear appropriate clothing to avoid skin contact.
Stability and reactivity
Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.
Disposal considerations
Disposal Recommendations: Collect for recycling or recovery if possible. The recommended method of disposal is incineration. Wherever possible, disposal should be in an on-site licenced chemical incinerator, if allowed by the incinerator licence or permit. If no on-site incinerator is available, dispose of material in a licenced commercial chemical incinerator.
Regulatory Requirements: Observe all local and national regulations when disposing of this material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
